Generalised idiopathic benign acanthosis nigricans with onset during infancy: report of two patients
DOI:
https://doi.org/10.18203/issn.2454-2156.IntJSciRep20174091Keywords:
Genaralised idiopathic benign acanthosis nigricans, Non-familial, Insulin resistance, ChildrenAbstract
Generalised acanthosis nigricans (AN) is usually seen in association with insulin resistance or internal malignancy in adults. Very rarely, this may occur in children without any evidence of systemic disease and runs a benign course. Its management requires only watchful waiting. Here, we report two children with benign AN who had onset of AN during infancy and showed spontaneous improvement during follow up for a mean duration of 7.7±0.14 years.
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References
Callen JP. Dermatologic manifestations in patients with systemic disease. In: Bolognia JL, Jorizzo JL, Rapini RP, editors. Dermatology. 2nd ed. Philadelphia; Mosby Elsevier; 2008: 76.
Piccolo V, Russo T, Picciocchi R, Errico M, Ametrano O, Moscarella E. Generalized Idiopathic Benign Acanthosis Nigricans in Childhood. Annals of Dermatol. 2013;25:375-7.
Dayal D, Jain H, Attri SV, Bharti B, Bhalla AK. Relationship of high sensitivity C-reactive protein levels to anthropometric and other metabolic parameters in Indian children with simple overweight and obesity. J Clin Diag Res. 2014;8(8):5–8.
Sinha S, Schwartz RA. Juvenile acanthosis nigricans. J Am Acad Dermatol 2007;57:502-8.
Das D, Das A, Kumar D, Gharami RC. Generalized benign acanthosis nigricans in an infant. Indian Dermatol Online J. 2014;5:116-8.
Denadai R, Souto RM, Auada-Souto MP. Generalized acanthosis nigricans without systemic disease associated. Dermatol Online J. 2013;19:19614.
Inamadar AC, Palit A. Generalized acanthosis nigricans in childhood. Pediatr Dermatol. 2004;21:277-9.
Dayal D, Jayaraman D, Sankhyan N, Singhi P. Acute Painful Neuropathy in a Girl with Type 1 Diabetes: Long Term Follow-Up. J Clin Diagn Res. 2016;10(5):1-2.
Kutlubay Z, Engin B, Bairamov O, Tuzun Y. Acanthosis nigricans: A fold (intertriginous) dermatosis. Clin Dermatol. 2015;33:466-70.
Berk DR, Spector EB, Bayliss SJ. Familial acanthosis nigricans due to K650T FGFR3 mutation. Arch Dermatol. 2007;143:1153-6.
Akovbyan VA, Talanin NY, Arifov SS, Tukhvatullina ZG, Musabayev AN, Baybekov IM, et al. Successful treatment of acanthosis nigricans with etretinate. J Am Acad Dermatol. 1994;31:118-20.
Skiljevic DS, Nikolic MM, Jakovljevic A, Dobrosavljevic DD. Generalized acanthosis nigricans in early childhood. Pediatr Dermatol. 2001;18:213-6.
Uyttendaele H, Koss T, Bagheri B, Schneiderman P, Silfen ME, Gallagher MP, et al. Generalized acanthosis nigricans in an otherwise healthy young child. Pediatr Dermatol. 2003;20:254-6.
Ozdemir M, Toy H, Mevlitoğlu I, Demirkesen C. Generalized idiopathic acanthosis nigricans treated with acitretin. J Dermatolog Treat. 2006;17:54-6.
Rai VM, Balachandran C. Generalized acanthosis nigricans in childhood. Dermatol Online J. 2006;12:14.
Gönül M, Kiliç A, Cakmak SK, Gül U, Ekiz OD, Ergül G. Juvenile generalized acanthosis nigricans without any systemic disease. Pediatr Int. 2009;51:595-7.
Mondal A, Debbarman P, Kumar P. Generalized benign acanthosis nigricans. Indian Pediatr. 2012;49:853.
