Retrospective analysis of mediastinal tumors in childhood
DOI:
https://doi.org/10.18203/issn.2454-2156.IntJSciRep20231446Keywords:
Mediastinal tumor, Childhood, Follow-upAbstract
Background: The aim of this study was to determine etiologic distribution, epidemiologic properties, treatment, clinical course and late effects of the treatment of the patients diagnosed with mediastinal tumor.
Methods: Patients under 18 years old diagnosed with mediastinal tumors between January 1990 and June 2011 at the 19 Mayis university department of child oncology were examined retrospectively.
Results: There were 50 (61%) males, 32 (39%) females with mediastinal tumor. Median age at diagnosis was 9.28 years (30 days-17.4 years). Most common symptoms were respiratory distress (29.2%) and cough (23.1%). Sixty eight cases (82.9%) were malignant. Two cases died before diagnosis. Thirty seven cases (45.1%) were located in anterior followed by 16 (19.5%) in middle and 23 (28%) in posterior mediastinum. Most common malignant tumors were lymphomas (n=46, 67.6%), followed by sarcomas (n=12, 17.6%), neural crest tumors (n=8, 11.8%) and germ cell tumors (n=2, 2.9%). Thirteen cases had vena cava superior syndrome and 4 cases had signs of spinal cord compression at the time of diagnosis. Forty eight cases (58.5%) were alive and symptom free on follow-up (mean 39.5 months, 3-139 months), and 22 (26.8%) were died. Sixteen cases (23.5%) had late effects. Overall survival for all malignant tumors were 60.5±7.8%.
Conclusions: Mediastinal tumors should be considered in children with acute progressive respiratory distress and cough. Early diagnosis is still most important factor for prognosis.
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References
Bhakta N, Force LM, Allemani C, Atun R, Bray F, Coleman MP et al. Childhood cancer burden: a review of global estimates. Lancet Oncol. 2019;20(1):e42-53.
WHO. International Childhood Cancer Day: Questions and Answers. Available at: http://www.who.int/cancer/media/news/Childhoodcancerday/en/. Accessed on 22 February, 2023.
Kolit Z, Şahin S, Davutoğlu C, Huri M. Effectiveness of a task-oriented training on occupational performance, functional independence, and fatigue in children with childhood cancer: a randomized-controlled trial. Cadernos Brasileiros de Terapia Ocupacional. 2021;29.
Muslu L, Kolutek R. Çocukluk çağı kanserleri ve sağlık okuryazarlığı. Güncel Pediatri. 2018;16(3):117-32.
Hutzen B, Ghonime M, Lee J, Mardis ER, Wang R, Lee DA et al. Immunotherapeutic challenges for pediatric cancers. Molecular Therapy-Oncolytics. 2019;15:38-48.
Erdmann F, Frederiksen LE, Bonaventure A, Mader L, Hasle H, Robison LL et al. Childhood cancer: survival, treatment modalities, late effects and improvements over time. Cancer Epidemiol. 2021;71:101733.
Sandoval JA, Malkas LH, Hickey RJ. Clinical significance of serum biomarkers in pediatric solid mediastinal and abdominal tumors. Int J Molecular Sci. 2012;13(1):1126-53.
Fish JD, Lipton JM, Lanzkowsky P. Lanzkowsky's manual of pediatric hematology and oncology. Academic Press. 2016;1.
Mutlu M, Karakaş T, Yarış N. Çocukluk çağı primer mediastinal tümörlü olguların değerlendirmesi. Tur J Pediatr. 2009;18:186-92.
Temes R, Allen N, Chavez T, Crowell R, Key C, Wernly J. Primary mediastinal malignancies in children: report of 22 patients and comparison to 197 adults. Oncologist. 2000;5(3):179-84.
Sairanen H, Leijala M, Louhimo I. Primary mediastinal tumors in children. Eur J Cardio-Thoracic Surg. 1987;1(3):148-51.
Tansel T, Onursal E, Dayıoğlu E, Başaran M, Sungur Z, Çamcı E et al. Childhood mediastinal masses in infants and children. Turk J Pediatr. 2006;48:8-12.
Freud E, Ben-Ari J, Schonfeld T, Blumenfeld A, Steinberg R, Dlugy E et al. Mediastinal tumors in children: a single institution experience. Clin Pediatr 2002;41(4):219-23.
Lam JCM, Chui CH, Jacobsen AS, Tan AM, Joseph VT. When is a mediastinal mass critical in a child? An analysis of 29 patients. Pediatr Surg Int. 2004;20(3):180-84.
Takeda SI, Miyoshi S, Akashi A, Ohta M, Minami M, Okumura M et al. Clinical spectrum of primary mediastinal tumors: a comparison of adult and pediatric populations at a single Japanese institution. J Surgical Oncol. 2003;83(1):24-30.
Grosfeld JL. Primary tumors of the chest wall and mediastinum in children. In Seminars in Thoracic and Cardiovascular Surg. 1994;6(4):235-9.
Stuart J, Simpson JS, Mann JR. Intracellular hydrogen transport systems in acute leukaemia. Bri J Haematol. 1970;19(6):739-48.
Kornberg A, Polliack A. Serum lactic dehydrogenase (LDH) levels in acute leukemia: marked elevations in lymphoblastic leukemia. Blood. 1980;56(3):351-5.
Pui CH, Dodge RK, Dahl GV, Rivera G, Look AT, Kalwinsky D et al. Serum lactic dehydrogenase level has prognostic value in childhood acute lymphoblastic leukemia. Blood. 1985;66:778-82.
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