Published: 2016-03-19

An intriguing case of Gardner Diamond Syndrome with conversion disorder

Shadab Shireen M. Aref, Nina Desai, Vibhor Pardasani, Mahendra K. Gupta, Shraddha Thakkar


Diamond-Gardner Syndrome or autoerythocyte sensitization is a rare syndrome characterized by spontaneous development of painful edematous skin lesions progressing to ecchymoses over the next 24 hours. Severe stress and emotional trauma always precede the skin lesion. We present here a case of 15 years old girl who presented with multiple ecchymotic patches over the body with conversion disorder. Baseline biochemical, hematological and immunological investigations were normal. Skin biopsy showed no evidence of vasculitis. All routine coagulation investigations were normal. Therefore the diagnosis of Gardner-Diamond Syndrome was made on purely clinical grounds. It was therefore a diagnosis of exclusion. A high index of suspicion and Psychiatric evaluation were necessary to make the diagnosis.


Diamond-Gardner Syndrome, Severe stress, Ecchymotic patches

Full Text:



Gardner FH, Diamond LK. Autoerythrocyte sensitization: A form of purpura producing painful bruising following autosensitization to red cells in certain women. Blood. 1955;10:675-90.

Ogston D, Ogston WD, Bennett NB. Psychogenic purpura. Br Med J. 1971;1:30.

Hanna WT, Fitzpatrick R, Krauss S, Machado E, Dunn CD. Psychogenic purpura (autoerythrocyte sensitization) South Med J. 1981;74:538-42.

YĆ¼cel B, Kiziltan E, Aktan M. Dissociative identity disorder presenting with psychogenic purpura. Psychosomatics. 2000;41:279-81.

James WD, Berger TG, Elston DM. 10th ed. Philadelphia: Saunders Elsevier; 2006. Andrew's mdiseases of the skin.

Anderson JE, De Goff W, McNamara M. Autoerythrocyte sensitization (psychogenic purpura): A case report and review of the literature. Pediatr Emerg Care. 1999;15:47-8.