Effect of probiotics in the treatment of gastrointestinal symptoms in patients with scleroderma


  • Afsaneh Enteshari-Moghaddam Department of Internal Medicine, School of Medicine, Ardabil University of Medical Science, Ardabil, Iran
  • Shafieh Movassaghi Department of Rheumatology, Tehran University of Medical Science, Tehran, Iran
  • Abdolrahman Rostamian Department of Rheumatology, Tehran University of Medical Science, Tehran, Iran




SSc, Gastrointestinal involvement, Probiotics


Background: Treatment of gastrointestinal symptoms in patients with systemic sclerosis has been a challenge for years. Drugs, immunosuppressive or anti-fibrotic have always been associated with complications. The effectiveness of probiotics as live microorganisms of nonpathogenic always was to treat the symptoms.

Methods:In this clinical trial, 37 patients with systemic sclerosis with mild to severe symptoms in the intervention and control groups were studied. Inventory (UCLA SCTC GIT 2.0) was used for rating the severity of the gastrointestinal tract. Collected data was analysed by statistical methods using SPSS.19.

Results: Improvement was seen in total score after the use of probiotics in gastrointestinal reflux condition ((P=0.001), gastric distention (P =0.001), emotional function ((P=0.001), social.

Conclusions:This study showed that probiotics were significantly effective in treatment of gastrointestinal symptoms in patients with systemic sclerosis.


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Cooper GS, Stroehla BC. The epidemiology of autoimmune diseases. Autoimmun Rev. 2003;2:119-25.

Bolster MB, Silver RS. Clinical features of systemic sclerosis. In: Hochberg MC, Silman AJ, Smolen JS. Rheumatology. Philadelphia: Mosby, 2011;1373-1386.

Gary S, Ralph CB, Sherine EG. Kelley's Textbook of Rheumatology. Tehran: Saunders, 2012.

Marie I. Gastrointestinal involvement in systemic sclerosis. Presse Med. 2006;35:1952-65.

Jaovisidha K, Csuka ME, Almagro UA, et al. Severe gastrointestinal involvement in systemic sclerosis: report of five cases and review of the literature. Semin Arthritis Rheum. 2005;34:689-702.

Tian XP, Zhang X. Gastrointestinal complications of systemic sclerosis. World J Gastroenterol. 2013;19:7062-8.

Khanna D, Nagaraja V, Gladue H. Measuring response in the gastrointestinal tract in systemic sclerosis. Curr Opin Rheumatol. 2013;25:700-6.

LeRoy EC, Black C, Fleischmajer R. Scleroderma (systemic sclerosis): classification, subsets and pathogenesis. J Rheumatol. 1988;15:202-5.

Lock G, Holstege A, Lang B. Gastrointestinal manifestations of progressive systemic sclerosis. Am J Gastroenterol. 1997;92:763-71.

Khanna D, Denton CP. Evidence-based management of rapidly progressing systemic sclerosis. Best Pract Res Clin Rheumatol. 2010;24:387-400.

Borivant M, Strober W. The mechanism of action of probiotics. Curr Opin Gastroenterol. 2007;23:679-92.

Mikelsaar M, Stsepetova J, Hutt P. Intestinal lactobacillus sp. Is associated with some cellular and metabolic characteristics of blood in elderly people. Anaerobe. 2010;16: 240-6.

Frech TM, Khanna D, Maranian P. Probiotics for the treatment of systemic sclerosis-associated gastrointestinal bloating/distention. Clin Exp Rheumatol. 2011;29:S22-5.

Cappello C, Tremolaterra F, Pascariello A. Randomized clinical trial (RCT) of a symbiotic mixture in patients with irritable bowel syndrome (IBS): effects on symptoms, colonic transit and quality of life. Int J Colorectal Dis. 2013;28:349-58.

Pourfarzi F, Enteshari-Mogaddam A, Yazdanbod A. The Effect of Probiotic Yogurt on Controlling the Symptoms of Irritable Bowel Syndrome. Journal of Ardebil Univer. 2011;11:26-32.

Tiev KP, Cabane J. Digestive tract involvement in systemic sclerosis. Autoimmun Rev. 2011;11:68-73.

Forbes A, Marie I. Gastrointestinal complications: the most frequent internal complications of systemic sclerosis. Rheumatology. 2009;48:iii36-9.

Thoua NM, Bunce C, Brough G. Assessment of gastrointestinal symptoms in patients with systemic sclerosis in a UK tertiary referral centre. Rheumatology. 2010;49:1770-5.

Schmeiser T, Saar P, Jin D. Profile of gastrointestinal involvement in patients with systemic sclerosis. Rheumatol Int. 2012;32:2471-8.

Gyger G, Baron M. Gastrointestinal manifestations of scleroderma: recent progress in evaluation, pathogenesis, and management. Curr Rheumatol Rep. 2012;14:22-9.

Al-Dhaher FF, Pope JE, Ouimet JM. Determinants of morbidity and mortality of systemic sclerosis in Canada. Semin Arthritis Rheum. 2010;39:269-77.






Original Research Articles