Distribution of ABO and Rh (D) allele frequency among the populations of Yilmana Denssa and Mecha, Ethiopia

Authors

  • Ayele Mandafro Department of Biotechnology, School of Biological and Chemical Sciences and Technology, Addis Ababa Science and Technology University, P. O. Box 1647 Addis Ababa, Ethiopia
  • Musin Kelel Department of Biotechnology, School of Biological and Chemical Sciences and Technology, Addis Ababa Science and Technology University, P. O. Box 1647 Addis Ababa, Ethiopia

DOI:

https://doi.org/10.18203/issn.2454-2156.IntJSciRep20161274

Keywords:

ABO blood, allele frequency, Rh factor

Abstract

Background: The distributions of ABO blood group and Rh (D) factor is important for population distribution and genetics studies in multi-ethnic countries. Such studies are not completely covered the parts of Ethiopia, a country with multi ethnic groups. Therefore, this study is designed to decipher the population blood group distribution frequency in the population of West Gojam.

Methods: A total of 200 Volunteer individuals were participated in this study as a study subject to determine blood group in the study population by the antigen-antibody agglutination test. The results of tests were subjected to allelic frequency distribution calculation using Panmictic index.

Results: The total of the two sites had O (r=0.624), A (p=0.2299) and B (q=0.1456) of allele frequency and the genotypic frequency were AA (p2=0.05285), AO (2pr=0.287), BB (q2=0.0212), BO (2qr=0.1818), AB (2pq=0.0669) and OO (r2=0.39). Out of the tested samples 91%, was recorded Rh+ in the same population, with frequency of 0.7 for allele D confirming the majority of the population in this area as Rh+. Fixation indices (F) for ABO gene were 17 and 22 Yilmana Denssa and Mecha respectively which was higher in Ylmana Denssa.

Conclusions: The Panmictic index (P)was 78 lower than Mecha site for ABO gene and the observed heterozygosity (Ho) for ABO gene was 0.53 indicating large genetic variations in populations of the study area. Therefore, the findings of this study can be used as a baseline for the genetic diversity of the study area as a reference for Ethiopian ABO blood group phenotypes and genotypes studies.

Metrics

Metrics Loading ...

References

Cavalli-Sforza L. Feldmann W. The application of molecular genetic approaches to the study of human evolution. Nat Genet. 2003;33:266-75.

Chakraborty S. Heterozygosity and Fixation Index for ABO Gene in Barak Valley populations. Not Sci Biol. 2011;3:7-11.

Reich D, Cargill M, Bolk S, Irel J, Sabeti P. Linkage disequilibrium in the human genome. Nature. 2001;411:199-204.

Tishkoff S. Kidd K. Implications of biogeography of human populations for ‘race’ and medicine. Nat Genet. 2004;36:21-7.

Jorde L, Wooding S. Genetic variation, classification and ‘race’. Nat. Genet. 2004;36:28-33.

Yamamoto F. ABO blood group system ABH oligosaccharide antigens, anti-A and anti-B, A and B glycosyl transferases and ABO genes. Immuno hematol. 2004;20:3-17.

Choot E, Tax H. Rijnders J. Prenatal typing of Rh and Kell blood group system antigens: The edge of a watershed. Transfus Med. 2003;17:31-44.

Mourant E, Kopec C, Sobezak D. The distribution of the Human blood groups and other Polymorphisms. 1976; Oxford University Press, London.

Tekeste Z, Petros B. The ABO blood group and Plasmodium falciparum malaria in Awash, Metehara and Ziwayareas, Ethiopia. Malaria J. 2010;9:280.

Tadesse H. Tadesse K. Assessing the association of severe malaria infection and ABO blood groups in northwestern Ethiopia J Vector Borne Dis. 2013;50:292-6.

Oyenike A, Omolade O. Frequency distribution of ABO, RH blood groups and blood genotypes among the cell biology and genetics students of University of Lagos, Nigeria. African Journal of Biotechnology. 2006;5:2062-5.

Atire F. Distribution of ABO and Rh Blood Groups among Students of Some Ethnic Groups at Dilla University, Ethiopia. International Journal of Genetics and Genomics. 2015;3:8-19.

Tesfaye K, Petros Y, Andargie M. Frequency distribution of ABO and Rh (D) blood group alleles in Silte Zone, Ethiopia, Egypt J. Med. Hum. Genet. 2014;16 (1).

Kaya H, Gündo du M, Akarsu E, Kiki I, Tekin B. The distribution of blood groups in Erzurum. Medical Journal of Atatürk University. 1999;31:20-2.

Bakare A, Azeez A, Agbolade O. Gene frequencies of ABO and rhesus blood groups and haemoglobin variants in Ogbomoso, South–West Nigeria. African Journal of Biotechnology. 2006;5:224-9.

Sadiq MA. Comparative study of some genetical triates of Ninawa population with Iraq population. J Education Scie. 1989;9:100-12.

Mouhaus A, Abbas H, Musa S, Mahawi K. A study of ABO blood group and Rhesus factor distribution among sample of Missan province population. Journal of Basrah Researches. 2010;36:48-53.

Chavhan A, Jadhao R, Pawar S. The study of Allelic Frequency of ABO and Rh D Blood Group among the Banjara Population of Akola District, Maharashtra, India. Journal of Anthropology. 2012;8:1973-2880.

Downloads

Published

2016-04-25

Issue

Section

Original Research Articles