Drug utilization pattern during pregnancy in Nekemte referral hospital: a cross sectional study

Authors

  • Fanaye Asfaw Department of Biotechnology Addis Ababa Science and Technology University, Addis Ababa, Ethiopia
  • Mekdes Bekele Shool of pharmacy, Wollega University, Nekemte, Ethiopia
  • Shemsiya Temam Department of Biomedical sciences, school of medicine and health sciences, Arsi University, Ethiopia
  • Musin Kelel Department of Biotechnology Addis Ababa Science and Technology University, Addis Ababa, Ethiopia

DOI:

https://doi.org/10.18203/issn.2454-2156.IntJSciRep20162809

Keywords:

Drug, Pregnancy, Prescription, Hospital, Female

Abstract

Background: Pregnancy is a period of great physiological changes to the mother and fetus in which every malfunction of the body as the result of drug use may lead to serious consequences in both. It is a period that demands special care to the health care service providers. Therefore, the objective of this project is to conduct across sectional study on drug utilization pattern during pregnancy in Nekemte referral hospital, Ethiopia from 2012-2013 that could lay base for the maternal care programs.

Methods: A purposive sampling was used to draw 100 pregnant women from the source population. Data were collected from the documented drug administration record of Nekemte referral hospital for all stages of pregnancy, types of drugs, roots of administration and dosage forms for all the pregnant female who were admitted to the hospital.  

Results: Among the pregnant women, who visited Nekemte referral hospital during the study period, the majority (96%) had a record for drug (s) and almost similar pattern of records were found in all wards for drug use. Of all the pregnant women, there was a high record for drug utilization of the women in the first trimester. Unemployed and uneducated pregnant females make the highest proportion.  There was also a prescription of potentially dangerous drugs during pregnancy in Nekemte referral hospital.

Conclusions: Many pregnant women were found using drugs during pregnancy in Nekemte referral hospital, including potentially harmful drugs. Therefore, there should be intensive assessment of pregnant women treatment in line with the US food and drug administration agency (FDA) risk category and locally operating regulations by considering risks and benefits to both mothers and the foetus in drug prescription and administration.

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References

Wacha J, Szijarto A. Probiotics and pregnancy. Orv Hetil. 2011;152(11):420- 6.

Lee E, Maenon M, Smith L, Weiss S, Zuckeraman I, Wutoh A. National patterns of Medication use during pregnancy. Pharmaco-epidemiology and drug safety. 2006;15:537-45.

Oren GK, Astuszak AP, Ito S. Drugs in pregnancy. New England Journal of medicine. 1998;338(16):1128-37.

Nordeng H, Eskild A, Nesheim G. 2001. Jacobsen Drug use in pregnancy among parous Scandinavian women. Norwegian Journal of Epidemiology. 2001;11(1):97-103.

D’az H. Prescription of Medications during pregnancy: accidents, compromises, and uncertainties. Pharmaco-epidemiology and Drug safety.2006;15:613-7.

Andrade SE, Gurwitz JH, Davis RL, Chan KA, Finkelsteein JA, Fortman K. Prescription drug use in pregnancy. American Journal of Obstetrics and Gynecology. 2004;191:398-407.

Gagne JJ, Maio V, Berghella V, Louis DZ, Gonnella JS. Prescription drug use during Pregnancy: a population- based study in Regione Emilia-Romagna, Italy. Eur Journal of clinical Pharmacology. 2008;64:1125-32.

Anonymous. Reviewer Guidance Evaluating the Risks of Drug Exposure in Human pregnancies. US department of Health and Human services, FDA Center for Drug Evaluation and research (CDER), Center for Biologics Evaluation and Research (CBER) 2005.

Ferenc BR, Brain L, Andrew E. Risk and Benefit of Drug Use during pregnancy. International Journal of medical sciences. 2005;2:100-6.

HWO. Iron deficient anemia assessment, prevention, and control. A guide for program managers. WHO information sheet. 2001;WHO/NHD/01.3:1-132.

Christian P, Stewart CP, LeClerq SC, Wu L, Kaz J, Keith P, et al. Antenatal and postnatal iron supplementation and childhood mortality in rural Nepal: A prospective follow-up in a Randomized, Controlled Community Trial. American Journal of epidemiology. 2009;170(9):1127-36.

Kalaivani K. Prevalence and consequences of anemia in pregnancy. Indian Journal of Medical Research. 2009;130:627-33.

Leppee M, Culig J, Eric M, Sijanovic S. The effects of benzodiazepines in pregnancy. ActaNeurol Belg. 2010;110(2):163-7.

Mc Elhatton P. The effects of benzodiazepine use during pregnancy and lactation. Reproductive Toxicology. 1994;8(6):461-5.

Whitelaw AG, Cummings AJ, McFadyen IR. Effect of maternal lorazepam on the neonate. British Medical Journal. 1981;282:1106-8.

McMullen G R, Van Herle AJ. Hirsutism and the effectiveness of spironolactone in its management. Journal of Endocrinological Investigation. 1993;16(11):925-32.

Conover E. Over-the-counter products: nonprescription medications, nutraceuticals, and herbal agents. Clin Obstet Gynecol. 2002;45(1):89-98.

Siu K, Lee W. Maternal diclofenac sodium ingestion and severe neonatal pulmonary hypertension. Journal of pediatrics and Child health. 2004;40(3):152-3.

Charles FL, Lora LA, Morton PG, Leonard L. Drug information Handbook: A Comprehensive Resource for all Clinicians and Healthcare professionals. Lexi-comp’s drug reference handbooks 15th edn. Lexi-comp; 2007: 160.

Andrade SE, Gurwitz JH, Davis RL, Chan KA, Kikelstein JA, Fortman K. Prescription drug use in pregnancy. Am J obstet Gynecol. 2004;191:398-407.

Mohammed MA, Ahmed JH, Bushra W, Aljadhey HS. Medications use among pregnant women in Ethiopia: A cross sectional study. Journal of Applied Pharmaceutical Science. 2013;3:116-23.

Marleen MH, Van-Gelder J, Roeleveld N, Nordeng H. Exposure to non-steroidal anti-inflammatory drugs during pregnancy and the risk of selected birth defects: a prospective cohort study. Plos One. 2011;6(7):22174.

Lemlem GG, Gomathi P. Assessment of drug use and effect in pregnant women attending antenatal care in hospitals of Mekelle, Tigray, Ethiopia. Journal of Drug Delivery & Therapeutics. 2014;4(6):75-82.

Admasie C, Wasie B, Abeje G. Determinants of prescribed drug use among pregnant women in Bahir Dar city administration, Northwest Ethiopia: a cross sectional study. Admasie et al. BMC Pregnancy and Childbirth. 2014;14:325.

Verma P, Thakur AS, Deshmukh K, Jha AK, Verma S, Routes of drug administration. International Journal of Pharmaceutical Studies and Research. 2010;1(1):54-9.

FDA. Pregnancy categories for prescription drugs. FDA Drug Bulletin. 1982;12:24

Bánhidy RF, Lowry B, Czeizel AE. Risk and benefit of drug use during pregnancy. International Journal of Medical Sciences. 2005;2(3):100-6.

Teixeira-Mendonc C, Henriques-Coelho T. 2013. Pathophysiology of pulmonary hypertension in newborns: Therapeutic indications. Rev Port Cardiol. 2013;32(12):1005-12.

Duman NB. Socio-Demographic and obstetric factors associated with depression during in turkey. American International Journal of Contemporary Research. 2012;2(11):17-26.

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Published

2016-08-06

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