Effects of ethanolic extracts of Datura metel on blood lipid profile of male albino rats


  • Kayode A. Arowora Department of Biochemistry, Federal University Wukari, Taraba State, Nigeria
  • Chinedu Imo Department of Biochemistry, Federal University Wukari, Taraba State, Nigeria
  • Chukwuma S. Ezeonu Department of Biochemistry, Federal University Wukari, Taraba State, Nigeria
  • Zuhairah I. Muhammad Department of Biochemistry, Federal University Wukari, Taraba State, Nigeria




Albino rats, Blood, Datura metel, Ethanolic extract, Lipid profile, Body weight


Background: This study was carried out to investigate the effects of Datura metel (leaf, seed and fruit) on blood lipid profile of male albino rats.

Methods: Thirty-five albino rats (8 weeks old) weighing between 66g and 84g were purchased and randomly allotted into 7 groups. The normal control (group 1) received normal saline, while groups 2 to 7 received extracts of Datura metel at low (300 mg/kg body weight) and high doses (600 mg/kg body weight). The extracts were administered orally for seven consecutive days, while the animals were sacrificed on the 8th day; blood samples were collected, allowed to stand for fifteen minutes and then centrifuged.  

Results: There was a general decreasing trend in the mean values of low density lipoprotein levels across  the groups, however, group 7 (with lowest value) was found to be significantly lower (p <0.05) than other groups when compared with the normal control. Also, there was a general decreasing trend in the values of high density lipoprotein compared with normal control group, however lowest value was recorded to be 1.35±0.06 mmol/l for group 5. There were no significant differences (p >0.05) in triglyceride levels across the groups, while total cholesterol in groups 5 and 6 had significant differences with values of 2.05±0.06 mmol/l and 2.13±0.10 mmol/l respectively when compared with the normal control.

Conclusions: This study suggests that ethanolic extracts of Datura metel have active ingredients that are capable of improving blood lipid profile and this might be useful in the management of cardiovascular diseases. 


Metrics Loading ...

Author Biography

Kayode A. Arowora, Department of Biochemistry, Federal University Wukari, Taraba State, Nigeria

Department of Biochemistry, Senior Lecturer.


John DB, Herin SG. Datura metel Linn. A plant with potential as antibacterial agent. International Journal of Applied Biology and Pharmaceutical Technology. 2011;2(2):429.

Pan Y, Wang X, Hu X. Cytotoxic with anolides from the flowers of Datura metel. Journal of National Production. 2007;70:1127-32.

Uzun E, Sariyara G, Adsersenb A, Karakocc B, Ötük G, Oktayoglua E, et al. Traditional medicine in Sakarya province (Turkey) and antimicrobial activities of selected species. Journal of Ethnopharmacology. 2004;95:287.

Raut B, Shreshtha AP. Ethenoveterinary practices in Western Morang, Nepal. International Journal of Pharmaceutical Science Research. 2012;3:182-8.

Gaur RD, Sharma J, Painuli RM. Plants used in traditional healthcare of livestock by Gujjar community of Sub-Himalayan tracts, Uttarkhand, India. Indian Journal of National Production Research. 2010;12:243-8.

Papadoyannis IN. Determination of Datura Alkaloids by using Chromatographic Techniques. Rev Natl Tox. 1995;3:310-6.

Khaton MM, Shaik MM. Review of Datura metel: a potential medicinal plant. Global Journal of Research on Medicinal plants and Indigenous plants. 2012;1(4):123-32.

Etibor TA, Ajibola MI, Buhari MO, Safiriyu AA, Akinola OB, Caxton-Martins EA. Datura metel Administration Distorts Medial Prefrontal Cortex Histology of Wistar Rats. World Journal of Neuroscience. 2015;5:282-91.

Brown SB, Goldstein JL. Drugs used in the treatment of hyperlipoproteinaemias. In: Galman AG, Rall TW, Nies AS, Taylor P. (eds) Goodman & Gilman’s. The Pharmacological Basis of Therapeutics. 8th edition. New York, NY: McGraw-Hill; 1992: 874-894.

Nwanjo HU. Efficacy of aqueous leaf extract of Vernonia amygdalina plasma lipoprotein and oxidative status in diabetic rat models. Niger J Physiol Sci 2005;20:39-42.

Ugwu O, Nwodo PC, Okwesili FC, Joshua PE, Odo CE, Ossai EC. Effect of ethanolic extract of Moringa oleifera on lipid profile of mice. Res J Pharm Biol Chem Sci. 2013;4(1):1324-32.

Ezekwesili CN, Obidoa O, Nwodo OFC. An effect of ethanol Extract of Acalypha torta leaves on the Lipid profile and serum Electrolytes of Rabbit, Niger. J Biochem Mol Biol. 2008;23(1):15-9.

Kannel WB, Castelli WB, Gordion DV, Manamora PM. Serum cholesterol, lipoprotein and risk of coronary heart disease. The framingham study. American J Internal Medicine. 1971;24:1.

Carlson LA, Bottiger LE. Ischaemic heart disease in relation to fasting values of plasma triglycerides and cholesterol. Lancet. 1972;1:865-8.

Fafunso M, Arowora KA. Nutritional effects of the lipids in some Nigerian leafy vegetables. West African Journal of Biological and Applied Chemistry. 1992;35(1-4):25-32.

Betteridget T, De-Wei Z, Rita G, Wan-Jin T, Jonathan CC, Helen HH. Structural requirements for PCSK9-mediated degradation of the low-density lipoprotein receptor. Proceedings of National Academy of Sciences. 2008;105(35):13045-50.

Harris WS, Murray MP. The comparative deductions of the plasma lipids and lipoproteins by dietary fat; Salmon oils versus vegetable oils. Metabolism. 1983;32(2):179-84.






Original Research Articles