Biochemical constituents of gallstones from indigenous blacks of Nigerian origin

Authors

  • Collins Amadi Department of Chemical Pathology and Metabolic Medicine, University of Port Harcourt Teaching Hospital, Port Harcourt
  • Promise N. Wichendu Department of Surgery, University of Port Harcourt Teaching Hospital, Port Harcourt

DOI:

https://doi.org/10.18203/issn.2454-2156.IntJSciRep20181846

Keywords:

Nigeria, Gallstone, Cholesterol stone, Total bilirubin, Triglyceride, Calcium

Abstract

Background: The biochemical constituents of gallstones predict its etiopathogenesis. Hence, this study is conducted to investigate the biochemical constituents of gallstones from indigenous Nigerian patients.

Methods: It was a retrospective study of the biochemical constituents of post-operative gallstones from 48 adult patients of the University of Port Harcourt Teaching Hospital, Nigeria. Records on age, sex, and concentrations of gallstone biochemical constituents (total cholesterol, triglyceride, total bilirubin, and calcium) from 1st January 2007 to December 2016 were extrapolated from laboratory records and analyzed using SPSS version 15.  

Results: The gallstones were of more females than the males (70.8% versus 29.2%; p=0.004). The mean age of the study cohorts was 46.88±7.96 with age range 31–64 years. No sex difference in age was observed, however, females were younger (males 50.39±8.31 versus females 45.47±7.52; p=0.056) with a lower age range (males 40–64 versus females 31- 63) than the males. The gallstone comprised of cholesterol stones (64.7%), mixed stones (22.9%), and pigment stones (12.5%). Though the females dominated among the three types of gallstones, the predominant stone type in both sexes remained cholesterol stones. Cholesterol lipid was the main constituent of the gallstones with no sex difference (p=0.227).

Conclusions: Cholesterol gallstones are the most common type of gallstones in this study and the cholesterol lipid is the most prevalent constituent of these gallstones. The females presented with more of the gallstones disease than the males.

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Author Biography

Collins Amadi, Department of Chemical Pathology and Metabolic Medicine, University of Port Harcourt Teaching Hospital, Port Harcourt

Consultant Chemical Pathologist, department of Chemical Pathology.

References

Njeze G. Gallstones. Nig J Surg. 2013;19:49–55.

Sanders G, Kingsnorth AN. Gallstones. BMJ. 2007;335:295–9.

Halldestam I, Enell EL, Kullman E, Borch K. Development of symptoms and complications in individuals with asymptomatic gallstones. Br J Surg. 2004;91:734–8.

Indar AA, Beckingham IJ. Acute Cholecystitis. BMJ. 2002;325:639–43.

Schaff EA. Gallstone disease:Epidemiology of gallbladder disease. Best Pract Res Clin Gastroenterol. 2006;20:981–96.

Rahman GA. Cholelithiasis and cholecystitis: Changing prevalence in an African community. J Natl Med Asso. 2005;97:1534–8.

Asuqup ME, Umoh MS, Nwagbara V, Inyang A, Agbor C. Cholecystectomy:Indications at University of Calabar Teaching Hospital, Calabar, Nigeria. Ann Afr Med. 2008;7:35–7.

Akute OO, Obajimi MO. Cholecystitis in Ibadan:an update. West Afr J Med. 2002;21:128–31.

Carey MC. Pathogenesis of gallstones. Am J Surg. 1993;165:410–9.

Carey MC. Pathogenesis of gallstones. Recenti Prog Med. 1992;83:379–91.

Jarrar B, Al-Rowaili MA. Chemical composition of gallstones from Al-Jouf province of Saudi Arabia. Malays J Med Sci. 2011;18:47 -52.

Chandra P, Kuchhal NK, Garg P, Pundir CS. An extended chemical analysis of gallstones. Indian J Clin Biochem. 2007:22:145–50.

Shalayel MHF, Idris SA, Elsiddig KE, Hamza AB, Hafiz MM. Biochemical composition of gallstones: Do different genders differ. Am J Bio Chem. 2013;1:1–6.

Sakar BCR, Chauhan UPS. A new method for determining micro quantities of calcium in biological materials. Anal Biochem. 1967;20:155–66.

Jendrassik L, Grof P. Colorimetric method of determination of bilirubin. Biochem Z. 1938;297:81–2.

Trinder P. Determination of glucose in blood using glucose oxidase with an alternative oxygen receptor. Ann Clin Biochem. 1969;6:24–7.

Tietz NW. Clinical guide to laboratory test, second edition. WB Sanders Company, Philadelphia, USA; 1990: 554–556.

Dauda MM, Yusuf LMD, Attah MM. Cholecystitis and cholelithiasis in adults in Zaria. Trop Doc. 2005;35;243–5.

Nerang S, Goyal P, Bal MS, Bandlish U, Goyal S. Gallstones size, number, biochemical analysis and lipidogram–an association with gallbladder cancer:a study of 200 cases. Int J Cancer Ther Oncol. 2014;2(3):020310.

Valdivieso V, Covarrubias C, Siegel F, Cruz F. Pregnancy and cholelithiasis:pathogenesis and natural course of gallstones diagnosed in puerperium. Hepatology. 1993;17:1–4.

Ravnborg L, Teilum D, Pederson LR. Gallbladder stones classified by chemical analysis of cholesterol stone. Scand J Gastroenterol. 1990;25:720–1.

Qiao T, Ma R, Luo X, Yang L, Luo Z, Zheng P. The systematic classification of gallbladder stones. Plos One. 2013;8:e74887.

Hussein SM. Quantitative analysis of chemical composition of gallbladder stones among cholecystectomy of Iraqi patients. Am J Res Comm. 2013;1:26–32.

Reshetnyak VI. Concept of the pathogenesis and treatment of cholelithiasis. World J Hepatol. 2012;4;18–34.

Saqid A, Shaik SS, Sodhar JM. Gallstones:frequencies of the patients attending surgical OPD at Isra Hospital Hyderabad. Professional Med J. 2014;21:386–90.

Jain S, Kanchan MC. Quantitative estimation of biochemical and inorganic constituents present in the gallstones. Acta Medica Scientia. 2015;2:24–6.

More EW. The role of calcium in the pathogenesis of gallstones. Hepatology. 1984;4:228–43.

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Published

2018-04-25

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Original Research Articles