Published: 2021-08-21

Advanced stage cervical carcinoma diagnosed one year after pregnancy: the importance of cervical cancer screening

Gayem Inayet Çelik, Yasam Kemal Akpak, Sercan Kantarci, Alaattin Karabulut, Serkan Oral


Cervical cancer is the most common gynecological malignancy during pregnancy. The incidence of cervical cancer during pregnancy is 0.004-0.1%. Cervical cancer accompanied by pregnancy may have severe maternal and fetal consequences. In our case, our patient died approximately 1 year after giving birth and 2 months after being diagnosed with cervical cancer. Among the treatment options, chemotherapy, radiotherapy and surgical treatment options were available alone or in combination. Type of treatment needed to be individualized and depended on stage, type of histology and gestational age. The aim of our study was to emphasize the importance of vaginal examination and its method during pregnancy in the diagnosis of cervical cancer, which was among the preventable cancers in pregnancy.


Cervical cancer, Pregnancy, Infertility treatment, Vaginal examination, Human papilloma virus

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Eibye S, Kjær SK, Mellemkjær L. Incidence of pregnancy-associated cancer in Denmark, 1977-2006. Obstet Gynecol. 2013;122(3):608-17.

Pentheroudakis G, Pavlidis N. Cancer and pregnancy: poena magna, not anymore. Eur J Cancer. 2006;42(2):126-40.

Sood AK, Sorosky JI, Mayr N, Anderson B, Buller RE, Niebyl J. Cervical cancer diagnosed shortly after pregnancy: prognostic variables and delivery routes. Obstet Gynecol. 2000;95:832-8.

Beharee N, Shi Z, Wu D, Wang J. Diagnosis and treatment of cervical cancer in pregnant women. Cancer Med. 2019;8(12):5425-30.

Han SN, Gziri M, Calsteren KV, Amant F. Cervical cancer in pregnant women: treat, wait or interrupt? Assessment of current clinical guidelines, innovations and controversies. Ther Adv Med Oncol. 2013;5(4):211-9.

Korenaga TK, Tewari KS. Gynecologic cancer in pregnancy. Gynecol Oncol. 2020;157(3):799-809.

Han J, Hu X, He X, Wang J, Mueller MD, Papadia A, et al. Cervical cancer in pregnancy: one case report and a review of current treatment recommendations. Gynecol Pelvic Med. 2019;2:10.

Ackermann S, Gehrsitz C, Mehlhorn G, Beckmann MW. Management and course of histologically verified cervical carcinoma in situ during pregnancy. Acta Obstet Gynecol Scand. 2006;85(9):1134-7.

Paraskevaidis E, Koliopoulos G, Kalantaridou S, Pappa L, Navrozoglou I, Zikopoulos K, et al. Management and evolution of cervical intraepithelial neoplasia during pregnancy and postpartum. Eur J Obstet Gynecol Reprod Biol. 2002;104(1):67-9.

Karam A, Feldman N, Holschneider CH. Neoadjuvant cisplatin and radical cesarean hysterectomy for cervical cancer in pregnancy. Nat Clin Pract Oncol. 2007;4(6):375-80.

Zagouri F, Sergentanis TN, Chrysikos D, Bartsch R. Platinum derivatives during pregnancy in cervical cancer: a systematic review and meta-analysis. Obstet Gynecol. 2013;121:337-43.

Akpak YK, Gun I. Advance stage small cell neuroendocrine carcinoma of cervix: a case report. East J Med. 2013;18(1):41-4.

National Health Commission Of The People's Republic Of China. Chinese guidelines for diagnosis and treatment of cervical cancer 2018 (English version). Chin J Cancer Res. 2019;31(2):295-305.

Hecking T, Abramian A, Domröse C, Engeln T, Thiesler T, Leutner, et al. Individual management of cervical cancer in pregnancy. Arch Gynecol Obstet. 2016;293(5):931-9.

Amant F, Calsteren KV, Halaska MJ, Beijnen J, Lagae L, Hanssens M, et al. Gynecologic cancers in pregnancy: guidelines of an international consensus meeting. Int J Gynecol Cancer. 2009;19(1):1-12.

Cesar JA, Santos GB, Sutil AT, Cunha CF, Sde CD. Pap smears among pregnant women in Southern Brazil: a representative cross-sectional survey. Rev Bras Ginecol Obstet. 2012;34(11):518-23.