International Journal of Scientific Reports <p>International Journal of Scientific Reports is an open access, international, peer-reviewed multidisciplinary science and technology journal. The journal's full text is available online at International Journal of Scientific Reports is dedicated to publishing research from all areas of science and technology. The journal has a broad coverage of Medical sciences, Dental sciences, Physiotherapy, Biological sciences, Pharmaceutical sciences, Earth and environmental sciences, Physical sciences. International Journal of Scientific Reports is one of the fastest communication journals and articles are published online within short time after acceptance of manuscripts. The types of articles accepted include original research articles, review articles, editorial, news, case reports, short communications, correspondence, images, problem solving, perspectives and new updates. It is published monthly and available in print and online version.</p> <p><em><strong>Aims and scope</strong></em></p> <p><strong>Biological sciences</strong></p> <p>Cancer, Structural biology, Biophysics, Zoology, Systems biology, Evolution, Biological techniques, Stem cells, Neuroscience, Genetics, Microbiology, Biotechnology, Computational biology and bioinformatics, Physiology, Biochemistry, Psychology, Ecology, Developmental biology, Drug discovery, Plant sciences, Chemical biology, Molecular biology, Immunology, Cell biology</p> <p><strong>Health sciences</strong></p> <p>Pathogenesis, Risk factors, Biomarkers, Diseases, Signs and symptoms, Anatomy, Medical research, Health care, Health occupations, Dental sciences, Physiotherapy, Pharmaceutical sciences</p> <p><strong>Earth and environmental sciences</strong></p> <p>Planetary science, Environmental sciences, Environmental social sciences, Ecology, Climate sciences, Solid Earth sciences</p> <p><strong>Physical sciences</strong></p> <p>Optics and photonics, Astronomy and planetary science, Nanoscience and technology, Mathematics and computing, Materials science, Chemistry, Engineering, Physics</p> <p> </p> <p><strong>Print ISSN:</strong> 2454-2156</p> <p><strong>Online ISSN:</strong> 2454-2164</p> <p><strong>Issues: 12 per year</strong></p> <p><strong>Email:</strong> <a href="" target="_blank" rel="noopener"></a>, <a href="" target="_blank" rel="noopener"></a></p> <p><strong>Publisher:</strong> <a href="" target="_blank" rel="noopener"><strong>Medip Academy</strong></a></p> <p><strong>DOI prefix: 10.18203</strong></p> <p>Medip Academy is a member of Publishers International Linking Association, Inc. (PILA), which operates <a href="" target="_blank" rel="noopener">CrossRef (DOI)</a></p> <p> </p> <p><strong>Manuscript Submission</strong></p> <p>International Journal of Scientific Reports accepts manuscript submissions through <a href="" target="_blank" rel="noopener">Online Submissions</a>:</p> <p>About the Journal &gt; <a title="Online Submissions" href="" target="_blank" rel="noopener">Online Submissions</a></p> <p>Registration and login are required to submit items online and to check the status of current submissions.</p> <p>Please check out the video on our YouTube Channel:</p> <p>Steps to register and submit a manuscript:<br /><a href="" target="_blank" rel="noopener"></a></p> <p>Problem Logging In-Clear cookies:<br /><a href="" target="_blank" rel="noopener"></a></p> <p>If you find any difficulty in online submission of your manuscript, please contact editor at <a href=""></a></p> <p> </p> <p><strong>Abbreviation</strong></p> <p>The correct abbreviation for abstracting and indexing purposes is Int J Sci Rep.</p> <p><strong> </strong></p> <p><strong>Abstracting and Indexing information</strong></p> <p>The journal is indexed with</p> <p><strong><a href=";journalId=43334" target="_blank" rel="noopener">Index Copernicus</a></strong>, </p> <p><strong><a href="" target="_blank" rel="noopener">Index Medicus for South-East Asia Region (WHO)</a></strong>,</p> <p><strong><a title="" href="" target="_blank" rel="noopener">Scilit (MDPI)</a></strong>,</p> <p><strong><a title=";referer=brief_results" href=";referer=brief_results" target="_blank" rel="noopener">OCLC (WorldCat)</a></strong>,</p> <p><a href="" target="_blank" rel="noopener">CrossRef</a>,</p> <p><a href="" target="_blank" rel="noopener">Journal Index</a>,</p> <p><a href="" target="_blank" rel="noopener">Google Scholar</a>,</p> <p><a title="LOCKSS" href="http://localhost/index.php/scirep/gateway/lockss" target="_blank" rel="noopener">LOCKSS</a>, </p> <p><a href="" target="_blank" rel="noopener">J-Gate</a>,</p> <p><a href=";format=full&amp;fIDnum=%7c" target="_blank" rel="noopener">SHERPA/RoMEO</a>,</p> <p><a href="" target="_blank" rel="noopener">ICMJE</a>, </p> <p><a href=";subAction=pub&amp;publisherID=3072&amp;journalID=35437&amp;pageb=1&amp;userQueryID=25467&amp;sort=&amp;local_page=1&amp;sorType=&amp;sorCol=1" target="_blank" rel="noopener">JournalTOCs</a>, </p> <p><a href="" target="_blank" rel="noopener">ResearchBib</a>.</p> Medip Academy en-US International Journal of Scientific Reports 2454-2156 Need of rural communities to be engaged and empowered for global health and wellness <p>For health and wellness rural communities do many things with whatever they have, use various modalities of actions for prevention, therapy of disorders, maintenance, promotion of health. Also, for everyday life they do various activities which affect their health. Present article is based on observations, information in context of activities by rural people for their health and wellness. Personal observations, experiences were added to information about actions by rural communities for health and wellness. Rural communities use their own wisdom, do many things with whatever they have for living a healthy life. They use various modalities during pregnancy, birth for mother, new born, persons of all ages. Therapies are used for pregnancy care, birth, post birth, other illnesses, injuries and so on. In modern day practice it has become essential to priorities modes of actions for best therapy, best outcome without harmful effects. In addition to various actions for prevention, therapy, maintenance and promotion of health and wellness, communities do other activities which impact their health. This needs sharing for best of global health. Communities use many modalities for therapy, prevention of disorders, rehabilitation and health promotion. Need is of learning from them, adding science to such modes if needed, robust evaluation of community actions with long term outcomes, cost-effectiveness, in various settings globally. World needs to know and use for healthy life and make communities aware of modern medicine, technology wherever essential for global health.</p> S. Chhabra Copyright (c) 2024 International Journal of Scientific Reports 2024-03-28 2024-03-28 10 4 130 134 10.18203/issn.2454-2156.IntJSciRep20240716 Atypical electroclinical presentation of Landau Kleffner syndrome: a case report of an 8 year old Nigerian child <p>Epileptic seizures account for common neurologic presentations in paediatric neurology units in developing countries. Atypical presentation of syndromic epilepsy may be missed especially sensory, psychic or autonomic manifestations. An 8 year old male Nigerian child presented with recurrent vomiting and delayed motor milestones, regression of speech (acquired aphasia) with unremarkable birth history or any underlying medical or surgical condition. He had delayed gross motor development and continuous bilateral polyspike waves of slow sleep on EEG. Self-limited autonomic epileptic seizure syndrome which was a strong differential of autonomic seizures in early childhood was not suggestive as his EEG findings failed to demonstrate occipital spike wave pattern nor did photic stimulation evoke any epileptiform waves. Child made significant clinical improvement with anticonvulsants, neuro vitamins, and behavioural therapy, evidenced by regain of non-verbal communication, resolution of autonomic symptoms and temper tantrums. A high index of suspicion should be applied in patients with acquired aphasia with subclinical or recurrent autonomic symptoms.</p> Chuks G. Nwala Omokhuale M. Ejemierele Copyright (c) 2024 International Journal of Scientific Reports 2024-03-28 2024-03-28 10 4 135 138 10.18203/issn.2454-2156.IntJSciRep20240717 The prevalence of premenstrual syndrome symptoms and associated factors among female medical students at Al-Andalus University: a cross-sectional study <p><strong>Background:</strong> Premenstrual syndrome (PMS) is a menstrual disorder defined as a cluster of various physical, emotional, and behavioural symptoms that negatively affect women’s quality of life. This cross-sectional study aimed to assess the prevalence of common PMS symptoms and determine their association with body mass index (BMI), lifestyle, dietary habits, perceived stress, menstrual flow, family history and family income among medical students at Al-Andalus University in Syria.</p> <p><strong>Methods:</strong> A sample of 205 female students were interviewed and filled out a questionnaire. All data were coded and entered into excel (Microsoft 2019). One-way analysis of variance (ANOVA) and Chi-square tests were used to evaluate the association between PMS symptoms and the studied factors. </p> <p><strong>Results:</strong> The most frequently reported PMS symptoms were anxiety (80%), bloating (74.6%), and breast tenderness (62.9%). Our study found a significant association between weight gain pre-menstruation and BMI (p=0.02). A significant relationship was found between increased premenstrual consumption of sweets and both breast tenderness and bloating (p=0.01). Daily consumption of coffee was significantly correlated with weight gain and headaches (p&lt;0.001). This study found a significant relationship between smoking cigarettes and abdominal and back pain (p=0.04, p=0.02, respectively). Smoking shisha was significantly associated with fatigue and bloating (p=0.01, p&lt;0.001, respectively). A significant relationship was found between menstrual flow and both abdominal pain and headaches (p=0.01, p=0.02, respectively).</p> <p><strong>Conclusions:</strong> A high prevalence of PMS symptoms was reported in Al-Andalus University female medical students. Additionally, this study found multiple significant associations between BMI, dietary habits, lifestyle, menstrual flow and the severity of symptoms.</p> Safa K. Salman Dina I. Esmandar Enana K. Sarem Ram F. Attaf Copyright (c) 2024 International Journal of Scientific Reports 2024-03-28 2024-03-28 10 4 95 101 10.18203/issn.2454-2156.IntJSciRep20240713 Estimation of thermodynamics properties as a measure of the extent of interference in a conducting polymer based electrochemical aqueous ion sensor <p><strong>Background:</strong> Interference of other ions towards the target analyte in an electrochemical sensor is typically estimated utilizing the peak reduction (PR) technique and the selectivity coefficient technique, both of which have limitations. In our earlier works, a scale of interference was developed using the barrier width (BW) technique based on Simmon’s model utilizing a conducting polymer-based sensor for the detection of Cd<sup>2+</sup> by square wave voltammetry (SWV). Also, a new scale of interference was generated with higher resolution by incorporating the BW technique along with adsorption isotherms and the PR technique.</p> <p><strong>Methods:</strong> The present work takes the investigation further at the electrode-electrolyte interface to explain the interference effect using thermodynamic parameters such as the partition coefficient, enthalpy and reorganization energy. The length of the reaction site for Cd<sup>2+</sup> can also measure interference effect. In this work, SWV for Cd<sup>2+</sup> detection in presence of interfering species at different temperatures were conducted, -ΔG<sub>ad</sub> values were extracted and all the thermodynamic parameters were evaluated. The novelty of this work lies in incorporation of these thermodynamic parameters along with BW values (d) to explain the interference phenomena.</p> <p><strong>Results: </strong>The variation of the thermodynamic properties for Cd<sup>2+</sup> in presence of interfering species were examined. Correlation coefficients were developed from the thermodynamic parameters and the d values to explain the extent of interference. </p> <p><strong>Conclusions:</strong> This study can provide information on the thermodynamic properties which can be predicted from BW technique. The correlation coefficients would help obtain an estimate of the interference with the need of lesser number of experiments.</p> Kusumita Dutta Siddhartha Panda Copyright (c) 2024 International Journal of Scientific Reports 2024-03-19 2024-03-19 10 4 102 110 10.18203/issn.2454-2156.IntJSciRep20240688 An analysis of indices and ratios in anthropometric body measurements among team sports athletes <p><strong>Background:</strong> Physical indices and proportions based on anthropometry are crucial for determining the performance of players in team sports. The study aims to analyze the anthropometric status, body mass and shape indices, including waist-to-hip and height ratios, among athletes from different team sports.</p> <p><strong>Methods: </strong>Study involved 135 male team-sport athletes specializing in basketball, handball, and volleyball, with 45 players in each sport. Researchers collected anthropometric data, including chronological age (CA), height (Ht), weight (Wt), body mass index (BMI), waist circumferences (WC) and hip circumferences (HC), waist-hip ratio (WHR), waist-height ratio (WHtR), and a body shape index (ABSI). To compare variables across groups, descriptive statistics and one-way ANOVA with LSD post-hoc tests used. Relationships within each group were examined using correlation analysis.</p> <p><strong>Results: </strong>The ANOVA findings indicated F-values (2, 132) for CA at 0.57, p=0.57, BMI at 0.59, p=0.56, WC at 2.10, p=0.13, WHR at 1.37, p=0.27, and ABSI at 1.41, p=0.25, respectively, revealing no significant disparities among the groups. Conversely, Ht at 13.36, p=0.00, Wt at 5.74, p=0.00, HC at 6.33, p=0.00, and WHtR at 3.60, p=0.03, respectively, highlighted significant variations between the groups. Furthermore, the correlation of BMI, WC, HC, WHR, WHtR, and ABSI in each group showed a strong positive correlation (p&lt;0.01).</p> <p><strong>Conclusions: </strong>Athletes in team sports were found to have similar body mass and shape indices, including ratios for WHR, while the WHtR ratio showed significant variations among the groups. Despite these differences, measures of athletes’ health metrics across these sports remain within safe, normal ranges.</p> Md. Hamidur Rahman J. P. Sharma Copyright (c) 2024 International Journal of Scientific Reports 2024-03-28 2024-03-28 10 4 111 119 10.18203/issn.2454-2156.IntJSciRep20240714 Trofinetide providing a promising avenue for the treatment of Rett syndrome <p style="margin: 0in; margin-bottom: .0001pt;">Rett syndrome (RTT) is a developmental disability associated primarily with the abnormal functioning of the nervous system. Affecting 1 in 10,000-15,000 women, it results from an inactivating modification in the X-linked genetic code, methyl-CpG-binding protein 2 (MECP2), which codes for a protein that binds to DNA and regulates transcription. Girls with RTT are born with normal prenatal and perinatal periods and appear to be in good health. Their psychomotor growth is typical up to their first or second year of life, at which point brain functional regression starts. Clinical signs of the regression include the emergence of stereotyped hand movements, a loss of fine motor skills, gait apraxia, verbal and nonverbal communication deficits, and epileptic seizures.</p> Raja Devendar Anum Fatima Shigri Maheera Khan Copyright (c) 2024 International Journal of Scientific Reports 2024-03-28 2024-03-28 10 4 139 140 10.18203/issn.2454-2156.IntJSciRep20240718 A meta-analysis evaluating the role of calcium channel alpha-2 delta-1 subunit in carcinogenesis <p>There is hardly found any study accumulating all the experiments reported with the expression of alpha-2 delta-1 (α2δ-1) in cancer cells. This meta-analysis aimed to advance our knowledge about the role of calcium channel alpha2 delta-1 subunit in carcinogenesis in the present time. PubMed searches for peer-reviewed articles were conducted using the keywords “α2δ-1 protein in oncogenesis”, “α2δ-1 protein expression in cancer cells”, and “α2δ-1 protein as cancer cell marker”. The databases were developed in accordance with PRISMA guidelines. Seventeen studies out of 80 citations met the inclusion criteria pertaining to α2δ-1 expression in different cancer cells. The cancer patterns were hepatocellular carcinoma in 41%, non-small cell lung carcinoma in 12% and laryngeal squamous cell carcinoma in 12%. The remaining studies included small-cell lung cancer (6%), gastric cancer (6%), pancreatic cancer (6%), hypopharyngeal squamous cell carcinoma (6%), breast cancer (6%) and glioblastoma multiforme (6%). α2δ-1<sup>+</sup> cells had a higher sphere-forming and tumorigenic efficiency in 76.5% of experiments. 58.8% experiments explored mechanistically in self-renewal efficiency and tumorigenesis of α2δ-1<sup>+</sup> cancer cells. The cancer cells expressing α2δ-1 have the potential to serve as cell surface markers for tumour-initiating cells and cancer stem cells. These intriguing findings open up a promising avenue for future research, focusing on the targeting of α2δ-1 as a potential therapeutic strategy for cancer treatment.</p> Chandan Raybarman Surajit Bhattacharjee Copyright (c) 2024 International Journal of Scientific Reports 2024-03-28 2024-03-28 10 4 120 129 10.18203/issn.2454-2156.IntJSciRep20240715