Neuromyelitis optica spectrum: a case report


  • Harshini Kancherla Department of PharmD, CMR College of Pharmacy, Kandlakoya, Hyderabad, India
  • Maheswari S. Kadimella Department of PharmD, CMR College of Pharmacy, Kandlakoya, Hyderabad, India
  • Ramya Bala Prabha Gelly Department of PharmD, CMR College of Pharmacy, Kandlakoya, Hyderabad, India
  • Ramo R. Tadikonda Department of PharmD, CMR College of Pharmacy, Kandlakoya, Hyderabad, India



Aquaporin-4, Demyelinating, Devic’s disease, Neuromyelitis optic spectrum


Neuromyelitis optica (NMO) or Devic's disease is a rare inflammatory, demyelinating autoimmune disease of the central nervous system that primarily affects women, most commonly in their 30s and 40s. NMOSD has been linked to several different illnesses including autoimmune disorders. Recurrent bouts of optic neuritis, myelitis and brainstem disorders are caused by serum antibodies (Abs) against the aquaporin-4 (AQP4) water channel. No AQP4-Abs are detected in some patients with NMOSD symptoms, but Abs against myelin-oligodendrocyte-glycoprotein (MOG). The term MOG-encephalomyelitis is now commonly used to describe this clinical disorder. Long segments of inflammation in the spinal cord (myelitis), severe optic neuritis and bouts of persistent vomiting and hiccoughs are all characteristics symptoms. This was the case of 30 year old female who presented with a chief complaint of weakness of both lower limbs, unable to walk, tingling and numbness. Based on her MRI findings revealed that the patient was diagnosed with NMO spectrum. She was treated with immunosuppressants and corticosteroids.


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Case Reports