Puffing topography and mouth level exposure of two closed-system Vype e-cigarettes

Authors

  • Krishna Prasad MRTP Science, BAT, Southampton, United Kingdom
  • Adam Gray MRTP Science, BAT, Southampton, United Kingdom
  • Lauren Edward MRTP Science, BAT, Southampton, United Kingdom

DOI:

https://doi.org/10.18203/issn.2454-2156.IntJSciRep20221343

Keywords:

Puffing topography, Puffing behaviour, Vype, Puff volume, Puff duration, Mouth level exposure

Abstract

E-cigarettes have the potential to reduce the harm caused by cigarette smoking; however, product likeability and product satisfaction are important in encouraging smokers to switch to less harmful products.  Actual use studies play a key part in evaluating the reduced risk potential of tobacco and nicotine products. User’s puffing behaviour, including puff duration and sensory effects were evaluated for two types of e-cigarette device: a coil-and-wick ‘pen-type’ device (Vype ePen3), and a ceramic block-and-plate ‘pod-type’ device (Vype ePod) with 18 mg/ml nicotine e-liquid. Puffing topography was recorded for these devices with two groups (n=52 each) of adult regular vapers (age 21-64 years) following a fixed 10 puffs protocol where subjects vaped through a special holder attached to a puffing analyser.  The sensory characteristics of the aerosol were evaluated using a questionnaire.  Mean puff volume was significantly greater (p≤0.0001) for ePen3 than for ePod (79.8 vs 49.4 ml), while puff duration and puff interval were similar (2.13 vs 2.29 s and 8.9 vs 10.3 s, respectively). Notably, MLE to aerosol and nicotine from ePen3 and ePod were similar (3.89 vs 4.80 mg and 0.06 vs 0.07 mg respectively) despite of very different designs of the devices.  Participants reported similar overall likeability and other sensory scores for ePen3 and ePod.  In summary, the puffing topography attributes support the CORESTA recommended method no. 81, (CRM81) puffing regime, used for in vitro and chemical analysis.  The MLE to nicotine per session from both the products were lower than a typical 6 mg cigarette.

Metrics

Metrics Loading ...

References

US Department of Health and Human Services. The Health Consequences of Smoking 50 Years of Progress: a Report of the Surgeon General, 2014. Available at: https://www.hhs.gov/surgeongeneral/ reportpublications/tobacco/index.html. Accessed on 28 February 2020.

Rodgman A, Perfetti TA. The Chemical Components of Tobacco and Tobacco Smoke. 2nd ed. USA: CRC Press; 2013.

Fowles J, Dybing E. Application of toxicological risk assessment principles to the chemical constituents of cigarette smoke. Tob Control. 2003;12(4):424-30.

Doll R, Peto R, Wheatley K, Gray R, Sutherland I. Mortality in relation to smoking: 40 years' observations on male British doctors. BMJ. 1994;309(6959):901-11.

Royal College of Physicians. Harm reduction in nicotine addiction: helping people who can’t quit. A report by the tobacco advisory group of the Royal College of Physicians. London: RCP; 2007.

Wipfli H. The Tobacco Atlas. American J Epidemiol. 2012;176(12):1193.

Public Health England. Health matters: stopping smoking - what works?, 2019. Available at: https://www.gov.uk/government/publications/healthmatters-stopping-smoking-what-works. Accessed on 28 February 2020.

Babb S, Malarcher A, Schauer G, Asman K, Jamal A. Quitting Smoking Among Adults - United States, 2000-2015. MMWR Morb Mortal Wkly Rep. 2017;65(52):1457-64.

Chaiton M, Diemert L, Cohen JE, Bondy SJ, Selby P, Philipneri A, et al. Estimating the number of quit attempts it takes to quit smoking successfully in a longitudinal cohort of smokers. BMJ Open. 2016;6(6):e011045.

Stratton K, Shetty P, Wallace R, Bondurant S. Clearing the smoke: the science base for tobacco harm reduction--executive summary. Tob Control. 2001;10(2):189-95.

Institute of Medicine (IOM). Clearing the Smoke—Assessing the Science Base for Tobacco Harm Reduction. Washington, DC: The National Academies Press; 2001.

Royal College of Physicians. Nicotine with smoke: Tobacco harm reduction, 2016. Available at: https://www.rcplondon.ac.uk/projects/outputs/nicotine-without-smoke. Accessed on 28 February 2020.

Royal College of General Practitioners. RCGP Position Statement on the use of electronic nicotine vapour products (e-cigarettes), 2017. Available at: https://www.rcgp.org.uk//media/Files/Policy/2017/RCGP-E-cig-position-statement-sept-2017. Accessed on 03 July 2020.

Margham J, McAdam K, Forster M, Liu C, Wright C, Mariner D, Proctor C. Chemical Composition of Aerosol from an E-Cigarette: A Quantitative Comparison with Cigarette Smoke. Chem Res Toxicol. 2016;29(10):1662-78.

FDA. Guidance for Industry- Modified Risk Tobacco Product Applications – Draft Guidance, 2012. Available at: https://www.fda.gov/media/83300. Accessed on 04 October 2021.

Murphy J, Gaca M, Lowe F, Minet E, Breheny D, Prasad K, et al. Assessing modified risk tobacco and nicotine products: Description of the scientific framework and assessment of a closed modular electronic cigarette. Regul Toxicol Pharmacol. 2017;90:342-57.

Voos N, Smith D, Kaiser L, Mahoney MC, Bradizza CM, Kozlowski LT, et al. Effect of e-cigarette flavors on nicotine delivery and puffing topography: results from a randomized clinical trial of daily smokers. Psychopharmacology (Berl). 2020;237(2):491-502.

Farsalinos K, Poulas K, Voudris V. Changes in Puffing Topography and Nicotine Consumption Depending on the Power Setting of Electronic Cigarettes. Nicotine Tob Res. 2018;20(8):993-7.

CRM (CORESTA RECOMMENDED METHOD). No. 81 Routine Analytical Machine for E-Cigarette Aerosol Generation and Collection – Definitions and Standard Conditions, 2015. Available at: https://www.coresta.org/routine-analyticae-cigarette definitions-and-standard. Accessed on 04 October 2021.

International Chamber of Commerce (ICC)/ESOMAR. International code on market, opinion and social research and data analytics, 2016. Available at: https://www.esomar.org/uploads/pdf/ prof. Accessed on 04 October 2021.

Slayford S, Frost B. A device to measure a smokers’ puffing topography and real-time puff by puff “tar” delivery. Beitr Tab Int. 2014;26(18):74-84.

Cunningham A, Slayford S, Vas C, Gee J, Costigan S, Prasad K. Development, validation and application of a device to measure e-cigarette users' puffing topography. Sci Rep. 2016;6:35071.

Jones J, Slayford S, Gray A, Brick K, Prasad K, Proctor C. A cross-category puffing topography, mouth level exposure and consumption study among Italian users of tobacco and nicotine products. Sci Rep. 2020;10(1):12.

Heide J, Adam TW, Jacobs E, Wolter JM, Ehlert S, Walte A, et al. Puff-Resolved Analysis and Selected Quantification of Chemicals in the Gas Phase of E-Cigarettes, Heat-Not-Burn Devices, and Conventional Cigarettes Using Single-Photon Ionization Time-of-Flight Mass Spectrometry (SPI-TOFMS): A Comparative Study. Nicotine Tob Res. 2021;23(12):2135-44.

Hensel EC, Eddingsaas NC, DiFrancesco AG, Jayasekera S, O'Dea S, Robinson RJ. Framework to Estimate Total Particulate Mass and Nicotine Delivered to E-cig Users from Natural Environment Monitoring Data. Sci Rep. 2019;9(1):8752.

McAdam K, Davis P, Ashmore L, Eaton D, Jakaj B, Eldridge A, et al. Influence of machine-based puffing parameters on aerosol and smoke emissions from next generation nicotine inhalation products. Regul Toxicol Pharmacol. 2019;101:156-65.

Behar RZ, Hua M, Talbot P. Puffing topography and nicotine intake of electronic cigarette users. PLoS One. 2015;10(2):e0117222.

Spindle TR, Breland AB, Karaoghlanian NV, Shihadeh AL, Eissenberg T. Preliminary results of an examination of electronic cigarette user puff topography: the effect of a mouthpiece-based topography measurement device on plasma nicotine and subjective effects. Nicotine Tob Res. 2015;17(2):142-9.

Kosmider L, Jackson A, Leigh N, O'Connor R, Goniewicz ML. Circadian puffing behavior and topography among e-cigarette users. Tob Regul Sci. 2018;4(5):41-9.

Gee J, Prasad K, Slayford S, Gray A, Nother K, Cunningham A, et al C. Assessment of tobacco heating product THP1.0. Part 8: Study to determine puffing topography, mouth level exposure and consumption among Japanese users. Regul Toxicol Pharmacol. 2018;93:84-91.

Helen G, Shahid M, Chu S, Benowitz NL. Impact of e-liquid flavors on e-cigarette vaping behavior. Drug Alcohol Depend. 2018;189:42-8.

Dawkins LE, Kimber CF, Doig M, Feyerabend C, Corcoran O. Self-titration by experienced e-cigarette users: blood nicotine delivery and subjective effects. Psychopharmacology (Berl). 2016;233(15-16):2933-41.

Hiler M, Breland A, Spindle T, Maloney S, Lipato T, Karaoghlanian N, et al. Electronic cigarette user plasma nicotine concentration, puff topography, heart rate, and subjective effects: Influence of liquid nicotine concentration and user experience. Exp Clin Psychopharmacol. 2017;25(5):380-92.

Hiler M, Karaoghlanian N, Talih S, Maloney S, Breland A, Shihadeh A, et al. Effects of electronic cigarette heating coil resistance and liquid nicotine concentration on user nicotine delivery, heart rate, subjective effects, puff topography, and liquid consumption. Exp Clin Psychopharmacol. 2020;28(5):527-39.

Spindle TR, Talih S, Hiler MM, Karaoghlanian N, Halquist MS, Breland AB, et al. Effects of electronic cigarette liquid solvents propylene glycol and vegetable glycerin on user nicotine delivery, heart rate, subjective effects, and puff topography. Drug Alcohol Depend. 2018;188:193-9.

Lee YO, Nonnemaker JM, Bradfield B, Hensel EC, Robinson RJ. Examining Daily Electronic Cigarette Puff Topography Among Established and Nonestablished Cigarette Smokers in their Natural Environment. Nicotine Tob Res. 2018;20(10):1283-8.

Kimber CF, Soar K, Dawkins LE. Changes in puffing topography and subjective effects over a 2-week period in e-cigarette naive smokers: Effects of device type and nicotine concentrations. Addict Behav. 2021;118:106909.

Spindle TR, Hiler MM, Breland AB, Karaoghlanian NV, Shihadeh AL, Eissenberg T. The Influence of a Mouthpiece-Based Topography Measurement Device on Electronic Cigarette User's Plasma Nicotine Concentration, Heart Rate, and Subjective Effects Under Directed and Ad Libitum Use Conditions. Nicotine Tob Res. 2017;19(4):469-76.

Robinson RJ, Hensel EC, Roundtree KA, Difrancesco AG, Nonnemaker JM, Lee YO. Week long topography study of young adults using electronic cigarettes in their natural environment. PLoS One. 2016;11(10):e0164038.

Lee YO, Morgan-Lopez AA, Nonnemaker JM, Pepper JK, Hensel EC, Robinson RJ. Latent Class Analysis of E-cigarette Use Sessions in Their Natural Environments. Nicotine Tob Res. 2019;21(10):1408-13.

Wagener TL, Avery JA, Leavens ELS, Simmons WK. Associated changes in e-cigarette puff duration and cigarettes smoked per day. Nicotine Tob Res. 2021;23(4):760-4.

Downloads

Published

2022-05-24