Clinical study of non-gall stone induced pancreatitis in a tertiary care centre

Varun Dogra; Rabia Nazir Ahmed; Javid Ahmad Peer; Ishfaq Ahmad Gilkar

doi:10.18203/issn.2454-2156.IntJSciRep20221052

Authors

Varun Dogra Department of Surgery, GMC Jammu, Jammu and Kashmir, India
Rabia Nazir Ahmed Department of Medicine, GMC Srinagar, Jammu, Jammu and Kashmir, India
Javid Ahmad Peer Department of General Surgery, School of Medical Science and Research, Sharda University, Greater Noida, Uttar Pradesh, India
Ishfaq Ahmad Gilkar Department of Surgery, GMC Jammu, Jammu and Kashmir, India

DOI:

https://doi.org/10.18203/issn.2454-2156.IntJSciRep20221052

Keywords:

Pancreatitis, Amylase, CT scan

Abstract

Background: Acute pancreatitis is a serious condition caused by an acute inflammatory cascade in the pancreas usually with symptoms of upper abdominal pain and increased pancreatic enzymes in blood, urine, peritoneal fluid at least 3 times above the normal. Presence of permanent, morphologic and functional damage differentiates acute and chronic pancreatitis. Aims and objectives: The aims and objectives of this study was to study the aetiology of non-gall stone induced pancreatitis.

Methods: It was an observational hospital-based study, which was designed and conducted in the department of general surgery, school of medical science and research, Sharda University, Greater Noida.

Results: The mean age of study population was 33 years. Among 100 patients 5 patients were in age group of ≤20 years, 47 in 21-40 years, 31 in 41-60 years and 17 in >60 years. The study consisted of 100 patients among which the male to female ratio was 1.7. In our study, in 18% of the patient’s alcohol was found to be the causative agent of acute pancreatitis. Hypertriglyceridemia and drugs as causative factor were seen in 15 and 7 patients respectively. No cause could be identified in 30% subjects.

Conclusions: Acute pancreatitis is a disease with high morbidity and mortality throughout the globe. Among the non-gall stone induced pancreatitis idiopathic and alcohol was found to be the commonest causative factor followed by others.

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References

Forsmark CE, Baillie J, AGA Institute Clinical Practice and Economics Committee, AGA Institute Governing Board. AGA Institute technical review on acute pancreatitis. Gastroenterology. 2007;132:2022-44.

Yang AL, Vadhavkar S, Singh G, Omary MB. Epidemiology of alcohol-related liver and pancreatic disease in the United States. Arch Intern Med. 2008;168:649-56.

Alsamarrai A, Das SL, Windsor JA, Petrov MS. Factors That Affect Risk for Pancreatic Disease in the General Population: A Systematic Review and Meta-analysis of Prospective Cohort Studies. Clin Gastroenterol Hepatol. 2014;12(10):1635-44.

Lee JK, Enns R. Review of idiopathic pancreatitis. World J Gastroenterol. 2007;13:6296-313.

Lehmann GA, Sherman S. Diagnosis and therapy of pancrease divisum. Gastrointest Endosclin N Am. 1998;8(1):55-77.

Sherman S, Lehman G. Sphincter of oddi dysfunction-giagnosis and treatment. J Pancrease. 2001;2.

Yang L, He Z, Tang X, Liu J. Type 2 diabetes mellitus and the risk of acute pancreatitis: a meta-analysis. Eur J Gastroenterol Hepatol. 2013;25:225-31.

Milheiro A, Medeiros A, Castro F. Acute pancreatitis-an analysis of consecutive 91 cases (1988-1991) with a brief review of literature. Acta Med Port. 1995; 12(10):1635-44.

Chang MC, Su CH, Sun MS, Huang SC, Chiu CT, Chen MC et al. Etiology of acute pancreatitis – a multi-center study in Taiwan. Hepatogastroenterol. 2003;50(53):1655-7.

Lee SP, Nicholls JF, Park HZ. Biliary sludge as a cause of acute pancreatitis. N Engl J Med. 1992;326(9):589-93.

Alsamarrai A, Stephanie AL, John A, Maxim S.Factors that affect risk for pancreatic diseases in the General Population: A Systemic Review and Meta-analysis of Prospective Cohort Studies. Clin Gastroenterol Hepatol. 2014;12:1635-44.