Utilization of gelatin methacryloyl scaffolds in the regeneration of tooth and its supporting tissues

Kirthanashri S. Vasanthan; Deborah Sybil; Priyanshu Kumar Shrivastava; Tanveer Ahmad

doi:10.18203/issn.2454-2156.IntJSciRep20222063

Authors

Kirthanashri S. Vasanthan Institute of Molecular Medicine and Stem Cell Research, (AIMMSCR), Amity University, Noida, Uttar Pradesh, India
Deborah Sybil Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Jamia Millia Islamia, New Delhi, India http://orcid.org/0000-0002-8793-3051
Priyanshu Kumar Shrivastava Faculty of Dentistry, Jamia Millia Islamia, New Delhi, India http://orcid.org/0000-0003-0078-3757
Tanveer Ahmad Multidisciplinary Centre for Advance Research and Studies, Jamia Millia Islamia, New Delhi, India

DOI:

https://doi.org/10.18203/issn.2454-2156.IntJSciRep20222063

Keywords:

Gelatin methacryloyl scaffolds, GelMA, Tooth regeneration, Tissue engineering

Abstract

Gelatin methacrylate (GelMA) due to its good biocompatibility, modifiable physical properties, and promotion of cellular adhesion, proliferation, and differentiation, serves as excellent scaffolds in tissue engineering and regeneration. These properties of GelMA make it a suitable choice for engineering of tooth and its supporting tissues. The complex spatial arrangement of the tooth along with the anisotropic nature of different tissues associated with it, make its regeneration challenging. Bioprinted GelMA scaffolds offer a great potential in mimicking the tooth architecture. In this study, GelMA scaffold was constructed by one pot method. The Fourier Transfer Infra red spectroscopy of GelMA confirmed the presence of amide bond at 1650 cm-1 (C=O stretching), 1550-1 (C-N stretching) and 1450-1. As evident from previous studies, the application of GelMA in whole tooth regeneration has not been studied exhaustively. However, GelMA has produced effective results in the regeneration of individual tooth components as well as the tooth germ. Therefore, this scaffold is proposed to be used in the whole tooth regeneration process because of its cytocompatiblity, cellular adhesion and tuneable mechanical properties.

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Author Biography

Deborah Sybil, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Jamia Millia Islamia, New Delhi, India

Professor,

Department of Oral and Maxillofacial Surgery,

Faculty of Dentistry, Jamia Millia Islamia,

New Delhi-110025, India.

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