Oral verrucous leukoplakia progression to malignancy: a case report with review of literature
DOI:
https://doi.org/10.18203/issn.2454-2156.IntJSciRep20223037Keywords:
Oral leukoplakia, Verrucous, Malignant transformationAbstract
Oral leukoplakia is one of most prevalent oral potential malignant disorders caused due to smoking. Non homogenous forms of leukoplakia have the higher rates of malignant transformation. Clinical diagnosis of these lesions is essential to avoid the fatality. Hereby, we report a case of verrucous leukoplakia which was histo-pathologically diagnosed as verrucous leukoplakia with moderate dysplasia and managed with surgical excision.
Metrics
References
Warnakulasuriya S, Johnson NW, Van der Waal I. Nomenclature and classification of potentially malignant disorders of the oral mucosa. J Oral Pathol Med. 2007;36:575-80.
Munde A, Karle R. Proliferative verrucous leukoplakia: An update. J Cancer Res Ther. 2016;12(2):469-73.
Statistics from the database of GLOBOCAN 2020. Available at: https://gco.iarc.fr/today/data/factsheets/ cancers/1-Lip-oral-cavity-fact-sheet.pdf4. Accessed on 12 Oct, 2022.
Warnakulasuriya S, Ariyawardana A. Malignant transformation of oral leukoplakia: a systematic review of observational studies. J Oral Pathol Med. 2016;45(3):155-66.
Bremmer JF, Brakenhoff RH, Broeckaert MA, Beliën JA, Leemans CR, Bloemena E et al. Prognostic value of DNA ploidy status in patients with oral leukoplakia. Oral Oncol. 2011;47:956-60.
Mao T, Xiong H, Hu X, Hu Y, Wang C, Yang L et al. DEC1: a potential biomarker of malignant transformation in oral leukoplakia. Braz Oral Res. 2020;34:e052.
Sarode GS, Sarode SC, Maniyar N, Sharma N, Yerwadekar S, Patil S. Recent trends in predictive biomarkers for determining malignant potential of oral potentially malignant disorders. Oncol Rev. 2019;13(2):424.
Von Zeidler SV, De Souza Botelho T, Mendonça EF, Batista AC. E-cadherin as a potential biomarker of malignant transformation in oral leukoplakia: a retrospective cohort study. BMC Cancer. 2014;14:972
Vidal L, Gillison ML. Human papillomavirus in HNSCC: recognition of a distinct disease type. Hematol/ Oncol Clin N Am. 2018;22(6):1125-42.
Ostwald C, Rutsatz K, Schweder J, Schmidt W, Gundlach K, Barten M. Human papillomavirus 6/11, 16 and 18 in oral carcinomas and benign oral lesions. Med Microbiol Immunol. 2003;192(3):145-8.
Feller L, Wood NH, Khammissa RAG, Lemmer J. Human papillomavirus-mediated carcinogenesis and HPV-associated oral and oropharyngeal squamous cell carcinoma-part 1: human papillomavirus-mediated carcinogenesis. Head Face Med. 2010;6:14.