Evaluating the demographic profile and mapping the prevalence of overactive bladder in benign prostrate hypertrophy patients:  a retrospective, observational study

Sandesh Warudkar; Amit B. Jain; Nilanj Dave; Ankita Shah

doi:10.18203/issn.2454-2156.IntJSciRep20222649

Authors

Sandesh Warudkar Medical Affairs, Intas Pharmaceuticals Limited, Ahmedabad, Gujarat, India
Amit B. Jain Medical Affairs, Intas Pharmaceuticals Limited, Ahmedabad, Gujarat, India
Nilanj Dave Medical Affairs, Intas Pharmaceuticals Limited, Ahmedabad, Gujarat, India
Ankita Shah Biostatistics and Programming, Lambda Therapeutic Research Ltd., Ahmedabad, Gujarat, India

DOI:

https://doi.org/10.18203/issn.2454-2156.IntJSciRep20222649

Keywords:

Benign prostrate hypertrophy, BPH, Overactive bladder, OAB, Treatment

Abstract

Background: The objectives of the study was to evaluate the demographic profile of benign prostatic hyperplasia (BPH) patients and prevalence of overactive bladder (OAB) among these patients.

Methods: A real-world, retrospective, observational study (DEMO-2) on BPH patients was conducted across India from April-2021 to March-2022. Demographics, BPH characteristics, status of OAB, and their management were evaluated.

Results: A total of 5881 BPH patients were included with a mean age of 65.3 years and mean BPH duration of 3.2 years. Majority (80.98%) of the patients had associated comorbidity; hypertension (50.2%), diabetes (26.9%) and dyslipidemia (13%) were the most common. Majority (63%) of the patients complained of incomplete bladder emptying. In BPH patients, 29.9% had OAB. These patients had a higher mean prostate volume (44.96 vs. 42.17 cc) and prostate specific antigen (PSA) levels (4.11 vs. 3.79 ng/ml) versus BPH patients without OAB. For BPH, tamsulosin was the most prescribed drug (85.90%) followed by dutasteride (66.90%); tamsulosin + dutasteride was most common combination therapy (32.6%). In BPH patients with OAB, 82% received OAB medications and solifenacin (63.9%) was the most common medication.

Conclusions: Majority of the BPH patients were between the ages of 50-75 years. Tamsulosin was the most commonly prescribed medication in BPH patients. Combination of tamsulosin and dutasteride was the mainstay of treatment. OAB was seen in 29.9% of the BPH patients, and solifenacin was the most commonly utilized (63.1%) medication in BPH patients with OAB. About 18% of these patients did not receive any specific medication for OAB. Adequate treatment strategies need to be adopted for BPH patients with OAB.

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