Enzyme therapy in sports injuries


  • Mohit R. Shete Department of Orthopaedics, Rajiv Gandhi Medical College and Chhatrapati Shivaji Maharaj Hospital, Thane, Maharashtra, India
  • James John Department of Medical Services, SIRO Clinpharm Ltd., Thane, Maharashtra, India




Proteolytic enzymes, Sprains, Ankle injury, Inflammation


Sports and exercise activities are helpful to increase overall health and physical fitness. But also, there is risk of different types of injuries such as sprains, strains, dislocations and fractures collectively known as sports injuries. Sports injuries, if not treated promptly and properly, may lead to lifelong disabilities or may affect athlete’s ability to participate in sports. Most of the sports injuries are affecting bones and soft tissues manifesting pain, inflammation and restricted mobility. The common treatment modalities are the use of non-steroidal anti-inflammatory drugs (NSAIDs) and corticosteroids for pain and inflammation management in sports injuries. But these drugs may lead to severe side effects in long term use. Also, NSAIDs and corticosteroids, do not promote crucial process of remodeling and repair of injury. Hence, there is a need for treatment modalities facilitating fast recovery with less side effects hastening the return to competition by injured athletes. Systemic enzyme therapy (SET) is the enzyme flavonoid combination administered orally and has been recommended since many years for the treatment of pain and inflammation. SET including bromelain, trypsin, rutoside combination has been evaluated and proven effective treatment option for faster recovery with reduced inflammation. These enzymes either in combination or individually show effect on injuries. This review explains types, pathophysiology, current treatment modalities, use of SET and its clinical evidences in sports injury.


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