Study the frequency of substance abuse in patients with perforated peptic ulcer disease


  • Mirsalim Seyedsadeghi Department of Surgery, Ardabil University of Medical Science, Ardabil, Iran
  • Hamed Zandian Department of Community Medicine, Ardabil University of Medical Science, Ardabil, Iran
  • Hamed Mikaeilimirak School of Medicine, Ardabil University of Medical Science, Ardabil, Iran



Peptic ulcer perforation, Peptic ulcer, Substance abuse


Background: Peptic ulcer perforation is one of the severe complications of peptic ulcer disease (PUD). Patients with perforated peptic ulcers usually are presented by the acute abdomen. In some studies, substance abuse is one of the peptic ulcer risk factors. Our study aimed to evaluate the frequency of substance abuse in patients with perforated peptic ulcers referred to Ardabil city hospital from January 2020 until March 2021.

Methods: This descriptive cross-sectional study was done on 60 patients with peptic ulcer perforation in Ardabil city hospital from January 2020 until March 2021. Data collected by a checklist and analyzed by statistical methods in SPSS version 25.

Results: Of all patients, 13 patients (19.7%) had substance abuse and all of them were male. Of all 13 patients with substance abuse, 9 (69.2%) had opium use.

Conclusions: The results showed that substance abuse among patients with peptic ulcer perforation, can be consider as a possible risk factor for peptic ulcer perforation, but more studies should perform to identify the effective factors and variables that can be main role in peptic ulcer perforation in patients.


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Sverdén E, Agréus L, Dunn JM, Lagergren J. Peptic ulcer disease. BMJ. 2019;367:15495.

Sung J, Kuipers E, El‐Serag H. Systematic review: the global incidence and prevalence of peptic ulcer disease. Alimentary Pharmacol Therapeutics. 2009;29(9):938-46.

Mangaroliya CD, Shekhawat NS. A clinical study of peptic ulcer perforation. Int J Adv Res Ideas Innovations Technol. 2019;5(1):537-42.

Sivaram P, Sreekumar A. Preoperative factors influencing mortality and morbidity in peptic ulcer perforation. Europ J Trauma Emergency Surg. 2018;44(2):251-7.

Sayehmiri K, Abangah G, Kalvandi G, Tavan H, Aazami S. Prevalence of peptic ulcer in Iran: Systematic review and meta-analysis methods. J Res Med Sci. 2018;23:1-6.

Barazandeh F, Yazdanbod A, Pourfarzi F, Sepanlou SG, Derakhshan MH, Malekzadeh R. Epidemiology of peptic ulcer disease: endoscopic results of a systematic investigation in Iran. Middle E J Digestive Dis. 2012;4(2):90-6.

Gyires K, Müllner K, Rónai AZ. Activation of central opioid receptors may induce gastric mucosal defense in the rat. J Physiol-Paris. 2001;95(1-6):189-96.

Amin‐Esmaeili M, Rahimi‐Movaghar A, Sharifi V, Hajebi A, Radgoodarzi R, Mojtabai R et al. Epidemiology of illicit drug use disorders in Iran: prevalence, correlates, comorbidity and service utilization results from the Iranian Mental Health Survey. Addiction. 2016;111(10):1836-47.

Yeþilkaya ÜH, Balcýoðlu YH, Ýlnem MC. Duodenal perforation in a patient with heroin use. Turkish J Clin Psychiatr. 2019;22:116-8.

Kahrom M, Kahrom H. Perforation of peptic ulcer following abrupt cessation of long-term opiate use. Surg Today. 2010;40(9):836-9.

Sarkar S, Nebhinani N, Gupta S, Parakh P, Basu D. Self-reported medical co-morbidity among 400 substance using patients at an addiction unit in India. J Substance Use. 2016;21(1):41-7.

Weintraub E, Dixon L, Delahanty J, Schwartz R, Johnson J, Cohen A, et al. Reason for medical hospitalization among adult alcohol and drug abusers. Am J Addictions. 2001;10(2):167-77.

Haji NE, Salehi N, Khoushkar A, Malekpour F, Najafi H, Shabani F et al. Perforated peptic ulcer in Loghman medical center, 1999-2005. 2006;48-53.

Sarsu SB. Unusual side effect of cannabis use: acute abdomen due to duodenal perforation. Int J Emergency Med. 2016;9(1):18.

Narayanan M, Reddy KM, Marsicano E. Peptic Ulcer Disease and Helicobacter pylori infection. Missouri Med. 2018;115(3):219-24.






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