Combined surgical and medical management for recurrent cellular angiofibroma of vulva in a young female - a case report
Keywords:Vulva, Angiofibroma, GnRH analogue, Histopathology
Cellular angiofibroma of the vulva is a benign tumor of mesenchymal origin in female and male genital tract composed of stromal spindle cells and mixture of adipose tissue, prominently vascular in nature. Here we present a case of recurrent cellular angiofibroma in a 27 years old young woman which was the 5th time recurrence when she presented to us. Diagnosis was confirmed by MRI, histopathology study and immunohistochemistry. With wide excision of tumor followed by GnRH analogue therapy post operatively, she is now tumour free even after 20 months of surgery.
Nucci MR, Granter SR, Fletcher CDM. Cellular angiofibroma: a benign neoplasm distinct from angiomyofibroblastoma and spindle cell lipoma. Am J Surg Pathol. 1997;21:636-44.
Lane E, Walker AN, Mullis EN, Etheridge JG. Cellular Angiofibroma of the Vulva. Gynecologic Oncology. 2001; 81(2): 326-9.
Dikmen Y, Yucebilgin MS, Kazandi M, Zekioglu O, Akalin T, Ozdemir N. Cellular angiofibroma of the vulva: report of a case. Eur J Gynaecol Oncol. 2004;25(2):242-4.
Dufau JP, Soulard R, Gros P. Cellular angiofibroma, angiomyofibroblastoma and aggressive angiomyxoma: members of a spectrum of genital stromal tumours? Ann Pathol. 2002;22(3):241-3.
Dargent JL, de Saint Aubain N, Galdon MG, Valaeys V, Cornut P, Noel JC. Cellular angiofibroma of the vulva: a clinicopathological study of two cases with documentation of some unusual features and review of the literature. J Cutan Pathol. 2003;30(6):405-11.
Flucke U, van Krieken JH, Mentzel T. Cellular angiofibroma: analysis of 25 cases emphasizing its relationship to spindle cell lipoma and mammary-type myofibroblastoma. Mod Pathol. 2011;24(1):82-9.
McCluggage WG, Perenyei M, Irwin ST. Recurrent cellular angiofibroma of the vulva. J Clin Pathol. 2002;55(6):477-9.
Dierickx I, Deraedt K, Poppe W, Verguts J. Aggressive angiomyxoma of the vulva: a case report and review of literature. Archives of Gynacol and Obstet. 2008;277(6):483-7.
Dahiya K, Jain S, Duhan N, Nanda S, Kundu P. Aggressive angiomyxoma of vulva and vagina: a series of three cases and review of literature. Archives of Gynecol and Obstet. 2011;283(5):1145-8.
Sun NX, Li W. Aggressive angiomyxoma of the vulva: case report and literature review,” Journal of International Medical Reasearch. 2010;38(4):1547-52.
Danesh A, Sanei MH. Aggressive angiomyxoma of the vulva: dramatic response to gonadotropin-releasing hormone agonist therapy. Journal of Research in Medical Sciences. 2007;12(4):217-21.
Hameed M, Clarkeb K, Amera HZ, Mahmetc K, Aisner S. Cellular angiofibroma is genetically similar to spindle cell lipoma: a case report. Cancer genetics and Cytogenetics. 2007;177(2):131-4.