Myoid hamartoma of breast: a rare case report with review of literature


  • Nimisha Dhankar Department of Pathology, Maulana Azad Medical College, New Delhi, India
  • Nita Khurana Department of Pathology, Maulana Azad Medical College, New Delhi, India
  • Jyoti Kumar Department of Radiology, Maulana Azad Medical College, New Delhi, India
  • Sushanto Neogi Department of Surgery, Maulana Azad Medical College, New Delhi, India



Mammary hamatroma, Myoid hamartoma, Breast lump, BIRADS


Myoid hamartomas of breast are extremely rare lesions with poorly defined pathogenesis. They are composed of differentiated mammary glandular and stromal structures with areas of smooth muscle differentiation. They are postulated to arise from walls of the blood vessels and/or muscularis mammillae of the areolae. They usual present as a well demarcated lump and it is difficult to diagnose them on clinical and radiological basis. Diagnosis requires demonstration of smooth muscle phenotype using immunohistochemistry by smooth muscle actin and desmin. Surgical resection is the curative treatment. We reported a case of myoid hamartoma in a 50-year-old postmenopausal lady with its clinical, radiological and histopathological discussion. The lesion presented as a painless lump and was initially reported as BIRADS 4a on mammography. Apart from the stroma showing spindle cell component with smooth muscle differentiation, the histopathology also showed epithelial changes including epithelial hyperplasia and columnar cell change.


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Charpin C, Mathoulin MP, Andrac L, Barberis J, Boulat J, Sarradour B, et al. Reappraisal of breast hamartomas. A morphological study of 41 cases. Pathol Res Pract. 1994;190(4):362-71.

Mester J, Simmons RM, Vazquez MF, Rosenblatt R. In situ and infiltrating ductal carcinoma arising in a breast hamartoma. AJR Am J Roentgenol. 2000;175(1):64-6.

Kai M, Tada K, Tamura M, Gomi N, Horii R, Akiyama F, et al. Breast cancer associated with mammary hamartoma. Breast Cancer Tokyo Jpn. 2012;19(2):183-6.

Davis JD, Riddell RH. Muscular hamartomas of the breast. J Pathol. 1973;111(3):209-11.

Kajo K, Zubor P, Danko J. Myoid (muscular) hamartoma of the breast: case report and review of the literature. Breast Care. 2010;5(5):331-4.

Ravakhah K, Javadi N, Simms R. Hamartoma of the breast in a man: first case report. Breast J. 2001;7(4):266-8.

Su CC, Chen CJ, Kuo SJ, Chen DR. Myoid hamartoma of the breast with focal chondromyoxid metaplasia and pseudoangiomatous stromal hyperplasia: A case report. Oncol Lett. 2015;9(4):1787-9.

Khoo JJ, Alwi RI, Abd-Rahman I. Myoid hamartoma of breast with chondroid metaplasia: a case report. Malays J Pathol. 2009;31(1):77-80.

Garfein CF, Aulicino MR, Leytin A, Drossman S, Hermann G, Bleiweiss IJ. Epithelioid cells in myoid hamartoma of the breast: a potential diagnostic pitfall for core biopsies. Arch Pathol Lab Med. 1996;120(7):676-80.

Herbert M, Sandbank J, Liokumovich P, Yanai O, Pappo I, Karni T, et al. Breast hamartomas: clinicopathological and immunohistochemical studies of 24 cases. Histopathology. 2002;41(1):30-4.

Magro G, Bisceglia M. Muscular hamartoma of the breast. Case report and review of the literature. Pathol Res Pract. 1998;194(5):349-55.

Murugesan JR, Joglekar S, Valerio D, Bradley S, Clark D, Jibril JA. Myoid hamartoma of the breast: case report and review of the literature. Clin Breast Cancer. 2006;7(4):345-6.

Amir RA, Sheikh SS. Breast hamartoma: a report of 14 cases of an under-recognized and under-reported entity. Int J Surg Case Rep. 2016;22:1-4.

Prabhu J, Moyle P. Recurrent myoid hamartoma of the breast mimicking malignancy. Radiol Case Rep. 2021;16(2):295-9.

Ko MS, Jung WS, Cha ES, Choi HJ. A rare case of recurrent myoid hamartoma mimicking malignancy: imaging appearances. Korean J Radiol. 2010;11(6):683-6.

Linell F, Ostberg G, Söderström J, Andersson I, Hildell J, Ljungqvist U. Breast hamartomas. An important entity in mammary pathology. Virchows Arch A Pathol Anat Histol. 1979;383(3):253-64.






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