An unusual radiological manifestation of a mandibular central giant cell granuloma


  • Bushra Ali Admani Department of Pediatrics, Dow University of Health Sciences, Baba-e-Urdu Road, Karachi, Pakistan
  • Fatima Siddiqui Department of Pediatrics, National Institute of Child Health, Rafiqui S. J. Shaheed Road, Napier Quarter, Karachi, Pakistan
  • Huda Ahmed Department of Medicine, Dow University of Health Sciences, Baba-e-Urdu, Karachi, Pakistan
  • Marya Hameed Jinnah Postgraduate Medical Centre, Rafiqui, Sarwar Shaheed Road, Karachi, Pakistan



Intra-osseous lesions, CT, Histopathology, Giant cells, Dental curettage


Central giant cell granuloma (CGCG) is an uncommon benign osseous lesion of the jaw. We present the case of an aggressive CGCG in a 16-year-old boy with a 5-month history of facial swelling and nasal obstruction. He was referred for a radiology consult for multiple expanding swellings on the right hemi-face. The swellings were reported to have an insidious onset, slow progression and no association with paresthesia, nasal discharge, or systemic symptoms. Extra oral examination revealed a diffuse swelling on the right side of the face which obliterated the nasolabial fold causing facial asymmetry. A face and neck computed tomography (CT) showed expansile multi loculated lytic lesions of the right mandibular ramus which involved the condyle and hard palate. Similar lesions were also found in the skull base. Scans showed fine internal septations and internal ground glass haze. It also revealed involvement of several teeth roots and surrounding soft tissues. A pre-operative intra-oral biopsy of the lesion revealed multinucleated giant cells, comprising of both spindle-shaped and round cells. Differential diagnosis helped determine the lesions as CGCG. This case helps to demonstrate the wide variation in the clinical, radiological, and histopathological features of CGCG and the importance of thorough investigation for timely diagnosis.


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Farrier SL, Farrier JN, Smart MK, Nash ES. A 10-year review of the occurrence and treatment of central giant cell granulomas, in a District General Hospital. J Oral Pathol Med. 2006:35(6):332-7.

Tosco P, Tanteri G, Iaquinta C, Fasolis M, Roccia F, Berrone S et al. Surgical treatment and reconstruction for central giant cell granuloma of the jaws: A review of 18 cases. J Craniomaxillofac Surg. 2009:37:380-7.

Curtis NJ, Walker Dm. A case of aggressive multiple metachronous central giant cell granulomas of the jaws: differential diagnosis and management options. Int J Oral Maxillofac Surg. 2005:34(7):0-808.

Stavropoulos F, Katz J. Central giant cell granulomas: a systematic review of the radiographic characteristics with the addition of 20 new cases. Dentomaxillofacial Radiology 2002:31(4):213-7.

Varshney S, Bist SS, Gupta N, Bhagat S, Bhavna K. Giant cell reparative granuloma (central) of maxilla: case report and review. Clini Rhinol Int J. 2010:3(3):177-80.

Ebrahimi H, Yazdani J, Pourshahidi S, Esmaeli F, Zenouz AT, Mehdipour M. Central giant cell granuloma of the posterior maxilla: a case report. J Dent Res Dent Clin Dent Prospects. 2008:2(2):71-5.

Adarsh K, Cariappa KM, Vasantha D, Monica S. Central giant cell granuloma: An uncommon presentation, Oral Maxillofac. Surg Cases. 2018:4(4):135-40.

Birgit K-L, Raihanatou D, Christoph G, Karl-Ludwig M, Ulrich J, Johannes K. Central giant cell granuloma of the jaws: A clinical, radiologic, and histopathologic study of 26 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006:101(3):0-354.

Jeyaraj P. Management of Central Giant Cell Granulomas of the Jaws: An Unusual Case Report with Critical Appraisal of Existing Literature. Ann Maxillofac Surg. 2019:9(1):37-47.






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