DOI: http://dx.doi.org/10.18203/issn.2454-2156.IntJSciRep20150205

Hepatocellular carcinoma in eastern India, a detail analytical report from a tertiary care hospital

Sudeb Mukherjee, Kingshuk Dhar, Suhana Datta, Apurba Kumar Mukherjee

Abstract


Background: Hepatocellular carcinoma is the one of the commonest tumour worldwide.  A detailed clinical profile including its etiology and vast presentation is not available in Eastern India.

Methods: Retrospective chart review of 90 patients with HCCwas done. Total 90 patients (male 81, female9)  fulfillingdiagnostic criteria for HCC adopted by Barcelona-2000 EASL conferencewere analyzed for clinical, etiological, biochemical and radiological profile.

Results: Underlying cirrhosis was seen in 60% cases with Hepatitis B virus being the most common (33.3%) etiologic agent followed by Alcoholism (26.6%) in cirrhotic range. In 76.7% of HCC patients have AFP level more than 500 unit and practically diagnostic of HCC. Almost all patients presented with advanced disease (96.7%). Only 3.3% of HCC patients presented with mild disease.

Conclusions: The characteristics of HCC in eastern India are somewhat different from the rest of worlds. Alcohol and HBV infection are the two most important etiology prevailing here. 

Keywords: HCC (Hepatocellular carcinoma), AFP (Alpha fetoprotein), HBV (Hepatitis B virus), HCV (Hepatitis C virus)


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