Leptospirosis-induced transverse myelitis and multiorgan failure: an uncommon manifestation in non-epidemic setting


  • Muhammad Hamza Gul Department of Medicine, Bacha Khan Medical College, Mardan, Pakistan
  • Aisha Siddiqui Department of Internal Medicine, Liaquat University of Medical and Health Sciences (LUMHS), Jamshoro, Pakistan
  • Farina Fatima Siddiqui Department of Internal Medicine, Liaquat University of Medical and Health Sciences (LUMHS), Jamshoro, Pakistan
  • Waqas Ahmad Department of Internal Medicine, Northwest Health Porter, Indiana, USA
  • Abdul Baseer Wardak Department of Surgery, Razia Bahlol Hospital, Afghanistan
  • Yugam Rajeshkumar Oza Department of Internal Medicine, Grodno State Medical University, Grodno, Belarus




Clinical manifestation, Infectious disease, Leptospirosis, Multiorgan failure, Transverse myelitis


Leptospirosis is a disease that can be transmitted from animals to humans. It is caused by a bacterium called Leptospira interrogans and is more common in tropical and subtropical regions. Despite being the most neglected tropical disease, it is a significant emerging and re-emerging disease, according to recent reports and reviews by the World Health Organization (WHO). Leptospirosis is widespread among humans and animals globally, and it is estimated that there are 1.03 million cases and 58,900 deaths annually, with a case fatality rate of 6.85%. Acute transverse myelitis (TM) is a rare neurological disease that affects the spinal cord. It is caused by various autoimmune reactions and is usually limited to several spinal cord segments. It has a poor prognosis. Our case report presents a unique situation where a patient developed multiorgan failure due to leptospirosis and also had a rare co-presentation of transverse myelitis.


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Togal T, Sener A, Yucel N, Demirbilek S, Akgun FS, Aydogan M, Ucar M, Ersoy MO. Intensive care of a Weil's disease with multiorgan failure. J Clin Med Res. 2010;2(3):145.

Costa F, Hagan JE, Calcagno J, Kane M, Torgerson P, Martinez-Silveira MS, et al. Global Morbidity and Mortality of Leptospirosis: A Systematic Review. PLoS Negl Trop Dis. 2015;9(9):e0003898.

Rajapakse S. Leptospirosis: clinical aspects. Clin Med (Lond). 2022;22(1):14-7.

Haake DA, Levett PN. Leptospirosis in humans. Curr Top Microbiol Immunol. 2015;387:65-97.

Gupta N, Wilson W, Ravindra P. Leptospirosis in India: a systematic review and meta-analysis of clinical profile, treatment and outcomes. Infez Med. 2023;31(3):290-305.

Petakh P, Isevych V, Kamyshnyi A, Oksenych V. Weil's Disease-Immunopathogenesis, Multiple Organ Failure, and Potential Role of Gut Microbiota. Biomolecules. 2022;12(12):1830.

Karpagam KB, Ganesh B. Leptospirosis: a neglected tropical zoonotic infection of public health importance-an updated review. Eur J Clin Microbiol Infect Dis. 2020;39(5):835-46.

Soo ZMP, Khan NA, Siddiqui R. Leptospirosis: Increasing importance in developing countries. Acta Trop. 2020;201:105183.

Wen X, Xu D, Yuan S, Zhang J. Transverse myelitis in systemic lupus erythematosus: A case report and systematic literature review. Autoimmun Rev. 2022;21(6):103103.

Kularathna MDSV, Kularatne SAM, Pathirage M, Nanayakkara PTMA. Severe leptospirosis complicated with multiorgan dysfunction successfully managed with plasma exchange: a case report. J Med Case Rep. 2021;15(1):584.






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