Thyroid hormone imbalance and the mechanism by which it causes memory loss

Authors

  • Faiza Riaz Department of Medicine, Sindh Medical College, Karachi, Sindh, Pakistan
  • Eman Javed Department of Medicine, Dow Medical College, Karachi, Sindh, Pakistan
  • Maida Ali Department of Medicine, Sindh Medical College, Karachi, Sindh, Pakistan

DOI:

https://doi.org/10.18203/issn.2454-2156.IntJSciRep20243498

Keywords:

Thyroid hormone, Memory loss, Hippocampus

Abstract

Thyroid hormone imbalance is the cause of many cognitive dysfunctions such as memory loss, anxiety and depression. A study conducted by Yu et al suggests that hypothyroidism as well as hyperthyroidism causes depression, anxiety and hippocampal dysfunction in rats. The mechanism of these dysfunctions is not yet completely understood.

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References

Yu D, Zhou H, Yang Y, Jiang Y, Wang T, Lv L, et al. The bidirectional effects of hypothyroidism and hyperthyroidism on anxiety- and depression-like behaviors in rats. Horm Behav. 2015;69:106-15. DOI: https://doi.org/10.1016/j.yhbeh.2015.01.003

Sahin L, Keloglan Müsüroglu S, Selin Cevik O, Cevik K, Orekici Temel G. Hyperthyroidism leads learning and memory impairment possibly via GRIN2B expression alterations. Brain Res. 2023;1802:148209. DOI: https://doi.org/10.1016/j.brainres.2022.148209

Taşkın E, Artis AS, Bitiktas S, Dolu N, Liman N, Süer C. Experimentally induced hyperthyroidism disrupts hippocampal long-term potentiation in adult rats. Neuroendocrinology. 2011;94(3):218-27. DOI: https://doi.org/10.1159/000328513

Yu D, Zhou H, Zou L, Jiang Y, Wu X, Jiang L, et al. Hippocampal Administration of Levothyroxine Impairs Contextual Fear Memory Consolidation in Rats. Front Cell Neurosci. 2017;11:223. DOI: https://doi.org/10.3389/fncel.2017.00223

Estrada F, Crosas JM, Ahuir M, Pérez-Muñoz S, Zabala W, Aguayo R, et al. Free Thyroxine Concentrations Moderate the Response to a Cognitive Remediation Therapy in People With Early Psychosis: A Pilot Randomized Clinical Trial. Front Psychiatry. 2020;11:636. DOI: https://doi.org/10.3389/fpsyt.2020.00636

Göbel A, Heldmann M, Göttlich M, Dirk AL, Brabant G, Münte TF. Effect of Mild Thyrotoxicosis on Performance and Brain Activations in a Working Memory Task. PLoS One. 2016;11(8):e0161552. DOI: https://doi.org/10.1371/journal.pone.0161552

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Published

2024-11-25

How to Cite

Riaz, F., Javed, E., & Ali, M. (2024). Thyroid hormone imbalance and the mechanism by which it causes memory loss . International Journal of Scientific Reports, 10(12), 458–459. https://doi.org/10.18203/issn.2454-2156.IntJSciRep20243498

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Section

Letter to the Editor