Epinephrine nasal spray ‘Neffy’: a novel advancement in the treatment of anaphylaxis

Authors

  • Mahtab Zafar Rahbar Medical and Dental College, Lahore, Pakistan
  • Suhaina Amir Dow University of Health Sciences, Karachi, Pakistan
  • Muhammad Saad Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan

DOI:

https://doi.org/10.18203/issn.2454-2156.IntJSciRep20250392

Keywords:

Epinephrine nasal spray, Neffy, Anaphylaxis

Abstract

Anaphylaxis is a severe, systemic allergic reaction characterized by rapid onset and potentially fatal outcomes if not treated immediately. It commonly results from exposure to allergens such as foods, insect stings, or medications. Recent studies indicate worldwide incidence to be approximately 46 cases per 100,000 population annually. Immediate administration of epinephrine is essential in preventing the escalation of symptoms, including hypotension, bronchoconstriction, and airway obstruction.

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References

Pühringer V, Jilma B, Herkner H. Population-based incidence of all-cause anaphylaxis and its development over time: a systematic review and meta-analysis. Front Allergy. 2023;4:1249280. DOI: https://doi.org/10.3389/falgy.2023.1249280

Dribin TE, Waserman S, Turner PJ. Who Needs Epinephrine? Anaphylaxis, Autoinjectors, and Parachutes. J Allergy Clin Immunol Pract. 2023;11(4):1036-46. DOI: https://doi.org/10.1016/j.jaip.2023.02.002

Ellis AK, Casale TB, Kaliner M, Oppenheimer J, Spergel JM, Fleischer DM, Bernstein D, Camargo CA Jr, Lowenthal R, Tanimoto S. Development of neffy, an Epinephrine Nasal Spray, for Severe Allergic Reactions. Pharmaceutics. 2024;16(6):811. DOI: https://doi.org/10.3390/pharmaceutics16060811

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Published

2025-02-21

How to Cite

Zafar, M., Amir, S., & Saad, M. (2025). Epinephrine nasal spray ‘Neffy’: a novel advancement in the treatment of anaphylaxis. International Journal of Scientific Reports, 11(3), 144–144. https://doi.org/10.18203/issn.2454-2156.IntJSciRep20250392

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Section

Letter to the Editor