Marham-i-Raal: a natural multifaceted formulation for enhanced wound healing

Authors

  • Kausar Ansari Department of Dermatology and Cosmetology, Hakim Syed Ziaul Hasan Government Autonomous Unani Medical College and Hospital, Bhopal, Madhya Pradesh, India
  • Mohd Rizwan Department of Dermatology and Cosmetology, Hakim Syed Ziaul Hasan Government Autonomous Unani Medical College and Hospital, Bhopal, Madhya Pradesh, India
  • Javed Alam Department of Surgery, Hakim Syed Ziaul Hasan Government Autonomous Unani Medical College and Hospital, Bhopal, Madhya Pradesh, India
  • Mohd Anzar Husain Department of Dermatology and Cosmetology, Hakim Syed Ziaul Hasan Government Autonomous Unani Medical College and Hospital, Bhopal, Madhya Pradesh, India

DOI:

https://doi.org/10.18203/issn.2454-2156.IntJSciRep20243808

Keywords:

Chronic wounds, Ulcers, Wound infection, Wound remodeling, Marham-i-Raal

Abstract

A wound is a disruption in the skin's or mucous membrane's integrity caused by mechanical, chemical, or thermal injuries. The wound healing is complex and involves three overlapping stages: inflammation, proliferation, and tissue remodeling. The duration of healing of a wound can vary, and several factors may influence this process, potentially leading to delays or suboptimal healing outcomes. To address wounds and facilitate healing, various topical and systemic treatments, including antiseptics, antibiotics, antifungal, and analgesics, are utilized. In Unani System of Medicine wound is described as ‘Tafarruq-i-Ittiṣāl’ (loss of continuity) called ‘Jarāḥat’. Marham-i-Raal is in use for centuries and has wonderful effects in Qurūḥ-i-Muzmina (chronic wounds), Qurūḥ-i-Jarāḥiyya (surgical wounds), Shiqāq al-Maq‘ad (fissure in ano) and in other skin conditions like- Nār Fārsī (eczema), and Qūbā (dermatophytosis). It is valued for its effectiveness, affordability, and minimal side effects. This potent remedy is particularly beneficial for chronic ulcers, providing intensive and rapid therapeutic responses. This review explores the properties of Marham-i-Raal based on classical Unani literature and contemporary scientific research. An in-depth examination of research articles and significant scientific data from sources such as Google Scholar, PubMed, and ResearchGate was conducted. The findings indicated that Marham-i-Raal is a highly effective and safe wound healing preparation with potent desloughing, antimicrobial, antiviral, antiseptic, and antifungal properties.

Metrics

Metrics Loading ...

References

Chhabra S, Chhabra N, Kaur A, Gupta N. Wound Healing Concepts in Clinical Practice of OMFS. J Maxillofac Oral Surg. 2017;16(4):403-23. DOI: https://doi.org/10.1007/s12663-016-0880-z

Panda S, Ray B. A Review of Wounds: Current Aspects and Novel Management. ISSN Online. 2023;2229-3566. DOI: https://doi.org/10.7897/2277-4343.140399

Arzani HM. Tibb-e-Akbar. New Delhi: Idara Kitab-u-Shifa. 2022;772.

Majoosi A. Kamil-e-sanat (Jild awwal translated by Kantoori H). New Delhi: Central Council for Research in Unani Medicine, Ministry of AYUSH, Govt. of India. 2010;240.

Baghdadi IH. Kitab al-Mukhtarat fi’l Tibb (Urdu translation) Part 1. New Delhi: Central Council for Research in Unani Medicine, Ministry of AYUSH, Govt. of India. 1978;296.

Sharif Khan HM, Asbab TS, Ahmad Rizwan HK. Part 4. New Delhi: Central Council for Research in Unani Medicine, Ministry of AYUSH, Govt. of India. 2010;352.

Mazhar H. Shah T. The canon of Medicine by Avicenna. New Delhi: Idara kitab-u-shifa. 2007;145:415-6.

Arzani HM. Mizan-ul-Tibb. New Delhi. Daftar-ul-Maseeh, Hyderabad. 2001;267.

Fazil M, Nikhat S. Topical medicines for wound healing: A systematic review of Unani literature with recent advances. J Ethnopharmacol. 2020;257:112878. DOI: https://doi.org/10.1016/j.jep.2020.112878

Razi Z. Kitabul Hawi (Urdu Translation) Volume 13th New Delhi: Central Council for Research in Unani Medicine, Ministry of AYUSH, Govt. of India. 2004;34-5.

Zehrawi AQ. Jarahiyat-e-Zehrawi (Urdu translation) New Delhi: Central Council for Research in Unani Medicine. 2012;144-51.

Das S. A concise textbook of surgery. 10th Edition. S Das Kolkata. 2018.

Son D, Harijan A. Overview of surgical scar prevention and management. J Korean Med Sci. 2014;29(6):751-7. DOI: https://doi.org/10.3346/jkms.2014.29.6.751

Nuutila K, Katayama S, Vuola J, Kankuri E. Human Wound-Healing Research: Issues and Perspectives for Studies Using Wide-Scale Analytic Platforms. Adv Wound Care (New Rochelle). 2014;3(3):264-71. DOI: https://doi.org/10.1089/wound.2013.0502

Shenoy KR, Nileshwar A. Manipal Manual of Surgery. 6th Edition. Volume 1. CBS Publisher and Distributors Pvt Ltd. 2023;99-104.

Mohan H. Textbook of Pathology. 8th edition. Jaypee Brothers Medical Publishers (P) Ltd. 2018;112-5.

Kareem HM. Keemya‑e‑Anasiri (An Urdu Translation of Qarabadin Qaadri written by Arzani HA). New Delhi: Central Council for Research in Unani Medicine. 2006;769.

Ahmad W, Alam S, Aquil Z. Herbo-Medicinal Formulation; Marham-i-Raal: A Potent Ointment for Acute and Chronic Wounds – A Review. Turk J Plast Surg. 2019;27(2):77-83. DOI: https://doi.org/10.4103/tjps.tjps_48_18

Ahmad W, Alam S, Aquil Z, Yunus S. A Comparative Clinical Study of Marham-i-Raal and Povidone-Iodine 5% Ointment in Non-healing Ulcers. Matrix Science Medica. 2023;7(3):66-70. DOI: https://doi.org/10.4103/mtsm.mtsm_2_23

All India Unani Tibbi. Qarabadeen Majeedi. Qorabadin E Majidi Urdu Hakimi Ilaj Unani Medicine. Delhi. 2019;340-1.

Ahmad W, Alam S, Aquil Z, Yunus S. Pyoderma Gangrenosum and Its Healing With Herbo-Medicinal Ointment Marham-i-Raal – A case study. Ayushdhara. 2020;6(5):2345-9. DOI: https://doi.org/10.7897/2277-4572.096188

National Formulary of Unani Medicine. Part I. New Delhi: Central Council for Research in Unani Medicine. 2006;165.

National Formulary of Unani Medicine. (Hindi) Part I. New Delhi: Central Council for Research in Unani Medicine. 2010;208.

Kabiruddin M. Bayaz-i-Kabir. Vol-2. New Delhi: Aijaz Publishing House. 2020;149.

Gilani G. Makhzanul Ilaj, Idara Kitab Us Shifa. New Delhi. 2019;795-6.

Ahmad Rizwan HK. Dehli ke Sahih Murakkabat. New Delhi: Aijaz Publishing House. 2002;295.

Kabiruddin M. Al-Qarabadin. 2nd edition. New Delhi: Central Council for Research in Unani Medicine. 2006;1059.

Ghani HN. Qarabadin-e-Najm-ul-Gani. New Delhi: Central Council for Research in Unani Medicine. 2010;1043.

Mokhtar MA, Ahmad MA, Nizami Q, Ahmad FJ, Rahman MM. Wound healing effect of an Unani formulation Marham-e-Ral in albino rats. Int J Adv Pharm Med Bio Allied Sci. 2014;2:20-4.

Ansari AP, Arokiarajan MS, Syed Akbar WA, Ahmed NZ, Anwar N. Investigating the Quality Control, Antimicrobial, and Antioxidant Evaluation of the Ointment “Marham-i-Raal” Used in the Unani System of Medicine. Pharm Biomed Res. 2024;10(1):47-56. DOI: https://doi.org/10.32598/PBR.10.1.1228.1

Hakeem MA. Bustanul Mufaradat. New Delhi: Idara Kitab‑us‑Shifa. 2002;290-565.

Ghani HN. Khazain-ul-advia. New Delhi: Idara Kitab-us shifa. YNM.

Ali HSS. Unani Advia-e-Mufrada. Qaumi Council Barai Farogh Urdu Zuban, New Delhi. 1999;215-95.

Fazmiya MJA, Sultana A, Rahman K, Heyat MBB, Sumbul, Akhtar F, et al. Current Insights on Bioactive Molecules, Antioxidant, Anti-Inflammatory, and Other Pharmacological Activities of Cinnamomum camphora Linn. Oxid Med Cell Longev. 2022;2022:9354555. DOI: https://doi.org/10.1155/2022/9354555

Khan, MS. Hasan Lari Q, Khan MA. Herb-O-Anim-O-Mineral Drugs Used to Cure Skin and Venereal Diseases in Unani Pathy – An Overview. 2018/10/30; P. 172-186

Khan MS, Hasan Lari Q, Khan MA. Therapeutic Uses of Mom Zard (Beeswax) in Unani System of Medicine - A Review. J Anal Pharm Res. 2016;3(1):00044. DOI: https://doi.org/10.15406/japlr.2016.03.00044

Kabiruddin H. Mukhzin-ul-Mufradat Al Maroof Khwasul-Adwia. New Delhi: Aijaz Publishing House. 2019;502.

Prasad V, Dorle AK. Evaluation of ghee-based formulation for wound healing activity. J Ethnopharmacol. 2006;107:38-47. DOI: https://doi.org/10.1016/j.jep.2006.02.006

Downloads

Published

2024-12-23

How to Cite

Ansari, K., Rizwan, M., Alam, J., & Husain, M. A. (2024). Marham-i-Raal: a natural multifaceted formulation for enhanced wound healing. International Journal of Scientific Reports, 11(1), 53–58. https://doi.org/10.18203/issn.2454-2156.IntJSciRep20243808

Issue

Section

Review Articles