Exacerbation of vitiligo following oral tranexamic acid therapy administered for the treatment of melasma: a case report
DOI:
https://doi.org/10.18203/issn.2454-2156.IntJSciRep20260366Keywords:
Tranexamic acid, Vitiligo, MelasmaAbstract
The presence of vitiligo has been identified as an independent risk factor for the development of melasma, and the two conditions may coexist in clinical practice. However, evidence regarding the optimal management of melasma in patients with concomitant vitiligo remains limited. Oral tranexamic acid has been increasingly recognized in recent years as a safe and effective treatment option for melasma. Nonetheless, its safety profile in patients who also have vitiligo has not been clearly established. In this report, we describe a case of a patient with melasma and coexisting vitiligo who developed a vitiligo flare following oral tranexamic acid therapy.
Metrics
References
Artzi O, Horovitz T, Bar-Ilan E, Shehadeh W, Koren A, Zusmanovitch L, et al. The pathogenesis of melasma and implications for treatment. J Cosmet Dermatol. 2021;20(11):3432-45. DOI: https://doi.org/10.1111/jocd.14382
Joge RR, Kathane PU, Joshi SH. Vitiligo: A Narrative Review. Cureus. 2022;14(9):e29307. DOI: https://doi.org/10.7759/cureus.29307
Lee HC, Thng TG, Goh CL. Oral tranexamic acid (TA) in the treatment of melasma: A retrospective analysis. J Am Acad Dermatol. 2016;75(2):385-92.
Bala HR, Lee S, Wong C, Pandya AG, Rodrigues M. Oral tranexamic acid for the treatment of melasma: A review. Dermatol Surg. 2018;44(6):814-25. DOI: https://doi.org/10.1097/DSS.0000000000001518
Perper M, Eber AE, Fayne R, Verne SH, Magno RJ, Cervantes J, et al. Tranexamic acid in the treatment of melasma: A review of the literature. Am J Clin Dermatol. 2017;18(3):373-81. DOI: https://doi.org/10.1007/s40257-017-0263-3
Chauncey JM, Patel P. Tranexamic Acid. In: StatPearls. Treasure Island (FL): StatPearls Publishing. 2025.
Sherman S, Duskin-Bitan H, Agiv T, Bar D, Marom-Haham L, Levi A, et al. Bidirectional association between vitiligo and melasma: A large-scale population-based study. Indian J Dermatol Venereol Leprol. 2025;1-7. DOI: https://doi.org/10.25259/IJDVL_1828_2024
Chiang PH, Lin YJ, Chiu YC, Chung WH, Ku CL, Ng CY. Feasibility of oral tranexamic acid for vitiligo patients with melasma. Dermatol Ther. 2021;34(5):e15047. DOI: https://doi.org/10.1111/dth.15047
Lee HC, Thng TG, Goh CL. Oral tranexamic acid (TA) in the treatment of melasma: A retrospective analysis. J Am Acad Dermatol. 2016;75(2):385-92. DOI: https://doi.org/10.1016/j.jaad.2016.03.001
Brenner M, Hearing VJ. The protective role of melanin against UV damage in human skin. Photochem Photobiol. 2008;84(3):539-49. DOI: https://doi.org/10.1111/j.1751-1097.2007.00226.x
Downloads
Published
How to Cite
Issue
Section
