The effect of first-trimester bleeding on the newborn birth weight: a retrospective study

Authors

  • Leila Sekhavat Department of Obstetrics and Gynecology, Shahid Sedughi Hospital, Shahid Sedughi University of Medical Sciences and Health Services, Yazd, Iran
  • Mojgan Hajisafari Tafti Department of Obstetrics and Gynecology, Shahid Sedughi Hospital, Shahid Sedughi University of Medical Sciences and Health Services, Yazd, Iran

DOI:

https://doi.org/10.18203/issn.2454-2156.IntJSciRep20253763

Keywords:

First trimester vaginal bleeding, First minute Apgar, 5-minute Apgar

Abstract

Background: Vaginal bleeding is a common complication during pregnancy and can cause some adverse pregnancy outcomes. The objective of this study is to evaluate the effect of first trimester bleeding in the current pregnancy on newborns Apgar.

Methods: A retrospective study was conducted on pregnant women who delivered at Shahid Sadoughi hospital in Yazd, Iran, between 2022 and 2023. They were singleton, nulliparous, non-diabetic women. Patients were categorized into two groups: exposure group (bleeding group) and control group (non-bleeding group), by using data from archived files. Apgar recorded in the newborn's file at the first minute and at the fifth minute after birth in both groups was noted.

Results: A total of 992 women were included in this study, with 218 exposure and 774 control groups. First minute Apgar score <7 was significantly increased in bleeding group. (22.5% versus 6.2%, p=0.02), while the five-minute Apgar score <7 did not increase significantly in this group.

Conclusion:  This study showed, there is positive correlation between first trimester vaginal bleeding and low first minute Apgar score in newborns.

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References

Gaillard R, Eric Ap Steegers AP, de Jongste JC, Hofman A, Vincent Wv Jaddoe V Wv. Tracking of fetal growth characteristics during different trimesters and the risks of adverse birth outcomes. Int J Epidemiol. 2014;43(4):1140-53. DOI: https://doi.org/10.1093/ije/dyu036

Gluckman PD, Hanson MA, Cooper C, Thornburg KL. Effect of in utero and early-life conditions on adult health and disease. N Engl J Med. 2008;359(1):61-73. DOI: https://doi.org/10.1056/NEJMra0708473

Hendriks E, Macnaughton H, Castillo Mackenzie M. First Trimester Bleeding: Evaluation and Management. Am Fam Physician. 2019;99(3):166-74.

Salim S, Ravishankar D, Vinod KVG. A study on first trimester vaginal bleeding and outcome of pregnancy in Thiruvananthapuram, Kerala. J Clin Obstet Gynaecol. 2020;6:143-6. DOI: https://doi.org/10.33545/gynae.2020.v4.i6c.745

Karimi A, Sayehmiri K, Vaismoradi M, Dianatinasab M, Daliri S. Vaginal bleeding in pregnancy and adverse clinical outcomes: a systematic review and meta-analysis. J Obstet Gynecol. 2024;44(1). DOI: https://doi.org/10.1080/01443615.2023.2288224

Bever AM, Pugh SJ, Kim S, Newman RB, Grobman WA, Chien EK, et al. Fetal Growth Patterns in Pregnancies with First-Trimester Bleeding. Obstet Gynecol. 2018;131(6):1021-30. DOI: https://doi.org/10.1097/AOG.0000000000002616

American Academy of Pediatrics Committee on Fetus and Newborn. The Apgar Score. Pediatrics. 2015;136(4):819-22. DOI: https://doi.org/10.1542/peds.2015-2651

Grünebaum A, Pollet S, Lewis D, De Four Jones M, Bornstein E, Adi Katz A. Is it time to modify the Apgar score? Am J Obstet Gynecol. 2024;230(3S):S988-9. DOI: https://doi.org/10.1016/j.ajog.2023.02.032

Alexandr M. Review of the Reliability and Validity of the Apgar Score. Adv Neonat Care. 2022;22(1):28-34. DOI: https://doi.org/10.1097/ANC.0000000000000859

Goswami IR, Whyte H, Wintermark P, Mohammad K, Shivananda S, Louis D, et al. Canadian Neonatal Network Investigators. Characteristics and short-term outcomes of neonates with mild hypoxic-ischemic encephalopathy treated with hypothermia. J Perinatol. 2020;40(2):275-83. DOI: https://doi.org/10.1038/s41372-019-0551-2

Chen HY, C Blackwell S, Chauhan SP. Association between apgar score at 5 minutes and adverse outcomes among Low-Risk pregnancies. J Matern Fetal Neonatal Med. 2022;35(7):1344-51. DOI: https://doi.org/10.1080/14767058.2020.1754789

Persson M, Razaz N, Tedroff K, Joseph KS, Cnattingius S. Five- and 10-minute Apgar scores and risks of cerebral palsy and epilepsy: population-based cohort study in Sweden. BMJ. 2018;360:k207. DOI: https://doi.org/10.1136/bmj.k207

Siddiqui A, Cuttini M, Wood R, Velebil P, Delnord M, Zile I, et al. Euro-Peristat Scientific Committee. Can the Apgar score be used for international comparisons of newborn health? Paediatr Perinat Epidemiol. 2017;31:338-45. DOI: https://doi.org/10.1111/ppe.12368

Li F, Wu T, Lei X, Zhang H, Mao M, Zhang J. The Apgar score and infant mortality. PLoS One. 2013;8:e69072. DOI: https://doi.org/10.1371/journal.pone.0069072

Hosseini MS, Yaghoubipour S. Late Pregnancy Outcomes in Women with Vaginal Bleeding in Their First Trimester. J Obstet Gynecol India. 2013;63:311-5. DOI: https://doi.org/10.1007/s13224-013-0389-z

Saraswat L, Bhattacharya S, Maheshwari A, Bhattacharya S. Maternal and perinatal outcome in women with threatened miscarriage in the first trimester: a systematic review. BJOG. 2010;117(3):245-57. DOI: https://doi.org/10.1111/j.1471-0528.2009.02427.x

Chaitanya N, Deepthisri T, Rohin. The study of first-trimester vaginal bleeding and its maternal and perinatal outcomes at a tertiary care center in Hyderabad. MRIMS J Health Sci. 2023;11(4):239-43. DOI: https://doi.org/10.4103/mjhs.mjhs_82_22

Siddu S, Dhama V, Chaudhary R, Singh S. The study of outcome of pregnancy with first trimester vaginal bleeding and its complications. Int J Reprod Contracept Obstet Gynecol. 2022;11(4):1150-5. DOI: https://doi.org/10.18203/2320-1770.ijrcog20220896

Bhatti D, Dhar T, Mandrelle K, Sohi I. Pregnancy Outcomes in Women with Vaginal Bleeding in Early Pregnancy. Chrismed J Health Res. 2022;9(3):188-92. DOI: https://doi.org/10.4103/cjhr.cjhr_99_21

Yakıştıran B, Yüce T, Söylemez F. First Trimester Bleeding and Pregnancy Outcomes: Case-Control Study. Int J Women’s Health Reprod Sci. 2016;4(1):4-7. DOI: https://doi.org/10.15296/ijwhr.2016.02

Kamble P D, Bava A, Shukla M, Nandanvar Y S. First trimester bleeding and pregnancy outcome. Int J Reprod Contracept Obstet Gynecol. 2017;6(4):1484-7. DOI: https://doi.org/10.18203/2320-1770.ijrcog20171414

Velez E, Baird, R H, Savitz, KE H. First-trimester bleeding characteristics associate with increased risk of preterm birth: data from a prospective pregnancy cohort. Human Reprod. 2012;27(1):54-60. DOI: https://doi.org/10.1093/humrep/der354

Hackney DN, Christopher JG. Vaginal bleeding in early pregnancy and preterm birth: systemic review and analysis of heterogeneity. J. Maternal-Fetal Neonatal Med. 2011;24(6):778-86. DOI: https://doi.org/10.3109/14767058.2010.530707

Chandrakala S, Reshmi MG. Maternal and fetal outcome in women experiencing first trimester vaginal bleed: a multicentric approach. Int J Reprod Contracept Obstet Gynecol. 2024;13(10):2765-9. DOI: https://doi.org/10.18203/2320-1770.ijrcog20242808

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Published

2025-11-24

How to Cite

Sekhavat, L., & Tafti, M. H. (2025). The effect of first-trimester bleeding on the newborn birth weight: a retrospective study. International Journal of Scientific Reports, 11(12), 430–434. https://doi.org/10.18203/issn.2454-2156.IntJSciRep20253763

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Original Research Articles