DOI: http://dx.doi.org/10.18203/issn.2454-2156.IntJSciRep20150214

Cartap poisoning: an unusual poisoning in North India

Monica Gupta, Dipti Handa, Amit Chaturvedi, Ram Singh, S. S. Lehl

Abstract


Cartap hydrochloride, an analogue of nereistoxin, belongs to a relatively new class of insecticidal chemistry, and its poisoning is uncommon in India. We describe a 50-year-old farmer who presented to emergency department in altered sensorium and alleged history of accidental inhalation of cartap hydrochloride while working in the fields. The patient improved with conservative management with BAL (British anti-lewisite) without any residual complications. As per the current medical literature; this is probably the first case report of cartap inhalational accidental poisoning. 

Keywords: Cartap hydrochloride, Pesticide, Inhalational poisoning

Full Text:

PDF

References


International Programme of Chemical Safety. The WHO recommended classification of pesticides by hazard and guidelines to classification 2000-2001. In: WHO, eds. WHO/PCA/0.1.5. Geneva: IOMC; 2002: 1-58.

Liao JW, Kang JJ, Liu SH, Jeng CR, Cheng YW, Hu CM, et al. Effects of cartap on isolated mouse phrenic nerve diaphragm and its related mechanism. Toxicol Sci. 2000;55:453-9.

Boorugu HK, Chrispal A. Cartap hydrochloride poisoning: a clinical experience. Indian J Crit Care Med. 2012;16:58-9.

Praveen Kumar AS, Amalnath D, Dutta TK. Cartap poisoning: a rare case report. Indian J Crit Care Med. 2011;15:233-5.

Senthilkumaran S, Balamurgan N, Thirumalaikolundusubramanian P. Emerging epidemic of cartap self-poisoning in Southern India: a prospective observational study. J Gen Med. 2007;19:54-5.

Senthilkumaran S, Balamurugan N, Menezes RG, Thirumalaikolundusubramanian P. Cartap poisoning: Additional thoughts. Indian J Crit Care Med. 2012;16:119.

Kurisaki E, Kato N, Ishida T, Matsumoto A, Shinohara K, Hiraiwa K. Fatal human poisoning with Padan: a cartap-containing pesticide. Clin Toxicol (Phila). 2010;48:153-5.

Raymond-Delpech V, Matsuda K, Sattelle BM, Rauh JJ, Sattelle DB. Ion channels: molecular targets of neuroactive insecticides. Invert Neurosci. 2005;5:119-33.

Koyama K. Miscellaneous pesticides and fungicides. Jpn J Acute Med. 1988;12:1457-61.

Abbasi SA, Krishnan S. Nereistoxin (metabolite of cartap). In: Abbasi SA, Krishnan S, eds. The new Japanese Pesticide Cartap. 2nd ed. New Delhi: APH Publishers; 1993: 6-7.

Namera A, Watanabe T, Yashiki M, Kojima T, Urabe T. Simple and sensitive analysis of nereistoxin and its metabolites in human serum using head-space solid-phase microextraction and gas chromatography-mass spectrometry. J Chormatogr Sci. 1999;37:77-82.

Kiyota K, Honma M, Shigeta M, Miyake Y, Sakamoto T, Aruga T, et al. Cartap intoxication - pharmacokinetic analysis. Jpn J Toxicol. 1994;7:263-70.