Relationship between Helicobacter pylori infection and pre-eclampsia among pregnant women in Ardabil


  • Fariba Kahnamouei-aghdam Faculty of Medicine, Ardabil University of medical science, Ardabil, Iran
  • Farhad Pourfarzi Faculty of Medicine, Ardabil University of medical science, Ardabil, Iran
  • Khadijeh Eslamnezhad Faculty of Medicine, Ardabil University of medical science, Ardabil, Iran



Pre-eclampsia, Helicobacter pylori, Cag A


Background: Studies have shown that certain infections can increase the risk of pre-eclampsia which one of the common infections among pregnant women was H. pylori with prevalence rate of 60-70% in developing countries. The aim of this study was to investigate the association between H. pylori infection and pre-eclampsia among pregnant women.

Methods: Blood and stool samples were taken from 108 women with pre-eclampsia and 108 healthy pregnant women. Blood samples analyzed by ELISA for specific antibodies against H. pylori cytotoxin associated gene A (Cag A) antigen and stool samples were studied in terms of the presence of H. pylori Cag A antigen. Collected data were analyzed using statistical methods in SPSS.20.  

Results: 30 cases (27.8%) of pre-eclampsia women and 34 (31.5%) of healthy women were sero-positive for Cag A antibodies that was not statistically significant difference. Whereas, 67 cases (62.4%) in the case group and 48 cases (44.4%) in the control group had Cag A antigen in stool samples that was statistically significant difference.

Conclusions: Results showed that, based on detection of H. pylori antigen in stool samples, frequency of active H. pylori in women with pre-eclampsia was 1.8 times higher than the healthy women.


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