Cytotoxicity, analgesic and anthelmintic studies of the different plant parts of Saraca indica Linn. (Family: Caesalpiniaceae)


  • Most. Nazma Parvin



Saraca indica, Cytotoxic, Analgesic, Anthelmintic


Background: Saraca indica or Saraca asoca belonging to the family Caesalpiniaceae. It is popularly known as Ashoka, is the most ancient tree of Bangladesh. This versatile plant has anti-cancer, anti-menorrhagic, anti-oxytocic, anti-microbial activity and has extended uses in ayurveda, unani and homeopathy. The present study attempts to investigate the cytotoxic and analgesic activities of the methanol extract of bark and the anthelmintic activity of the leaf extract of Saraca indica.

Methods: The cytotoxic activity of the methanol extract of the bark was performed by brine shrimp lethality bioassay and analgesic potential of the bark extract was evaluated using both acetic acid induced writhing test and tail-flick tests to understand the central analgesic activity using Swiss Albino mice as experimental animal. Anthelmintic activity of the leaf extract was performed by observing the time of paralysis and the time of death of earthworms, Pheretima posthuma.  

Results: The methanol extract of the bark showed moderate cytotoxic activity when compared with the standard drug vincristine sulphate. The results of analgesic activities suggested that the methanol extract of the bark possess significant analgesic activity in mice, which is comparable to the standard drug, diclofenac-Na. The fresh juice extract of the leaf of S. indica showed potent anthelmintic activity when compared with standard drug, albendazole.

Conclusions: Our present study, demonstrates the cytotoxic, analgesic and anthelmintic, properties of Saraca indica, which validate its use in traditional medicine.


Metrics Loading ...

Author Biography

Most. Nazma Parvin

Department of Pharmacy, Stamford University Bangladesh, Dhaka, Bangladesh


Sasmal S, Majumdar S, Gupta M, Mukherjee A, Mukherjee PK. Pharmacognostical, phytochemical and pharmacological evaluation for the antipyretic effect of the seeds of Saraca asoca Roxb. Asian Pac J of Trop Biomed. 2012;2(10):782-6.

Kirtikar KR, Basu BD, An ICS. Indian Medicinal Plants. Volume 2. Derhadun: International Book Distributors; 2005.

Anonymous. Indian Medicinal Plants, A Compendium of 500 Species, Vol 5, Chennai: Orient Longman Pvt Ltd; 2006.

Nadkarni AK, KM Nadkarni’s. Indian Materia Medica. Volume 1. Mumbai: Bombay Popular Prakashan; 2005.

Kashyapa K, Chand R. The Useful Plants of India. National Institute of Science Communication and information Resources, CSIR. New Delhi, 2006.

Joy PP, Thomas J, Mathew S, Skaria BP. Medicinal Plants. Kerala Agricultural University, Ernakulam. 1998.

Ghani A. Medicinal Plants of Bangladesh. Asiatic Society of Bangladesh, Dhaka. 2003;2:372.

Hasan SMR. Phytochemical and Pharmacological Investigations of Commelina benghalensis Linn. M. Pharm. Thesis. Department of Pharmacy, Jahangirnagar University. 2009.

Basak A, Hossain ML, Parvin MN. Evaluation of phytochemical and pharmacological activities of Bacopa monnieri (L.). Int J Sci Rep. 2016;2(10):242-7.

Meera S, Kumar NS, Guptatyam VSS. Screening of Anti-Arthritic, Anti-Inflammatory and Analgesic Activity of a Polyherbal Formulation. Int J pharmacol. 2008;4(5):398–402.

Hasan SMR. Phytochemical and pharmacological investigations of Commelina benghalensis Linn. M. Pharm. Thesis. Jahangirnagar University. 2009.

Singh D, Swarnka RCP. Khan FA. (2002) Anthelmintic resistance in Gastrointestinal nematodes in livestock in India J Vet Parasit. 2002;16:115-30.

Patil S, Dave AK, Singh VK, Jagannadham MV. In-vitro Anthelmintic Activity of Indian Medicinal Plant. J Agric Food Chem. 2009;55(14):5809-18.

Mishra A, Kumar A, Rajbhar N, Kumar A. Phytochemical and Pharmacological Importance of Saraca indica. JPCBS. 2013;2(2):1009-13.

Mohod SP, Jangde CR, Narnawore SD, Rant S. Experimental evaluation of analgesic property of bark of skin of Saraca indica (Ashoka) and Shorea robusta (Shal). JAPS. 2014;4(2):62-5.

Sarojini N, Manjari SA, Kanti CC. Phytochemical screening and anthelmintic activity study of Saraca indica Leaves extracts. In Res J Pharm. 2011;2(5):194-7.






Original Research Articles