Published: 2019-04-27

Facial paralysis probably related to systemic isotretinoin

Ömer Kutlu, İlknur Balta, Engin Karaarslan, Emine Esra Kıratlı Nalbant, Göğem İmren, Hatice M. Ekşioğlu


We report a patient with severe acne who developed facial paralysis after two months of treatment with oral isotretinoin. Drug withdrawal resulted in a complete clinical recovery. Our case and a review of the literature indicate that oral isotretinoin might be capable of causing a dysfunction of predominantly sensory nerve fibers in some individuals. Clinicians should be aware of possible neurological sensorial symptoms during isotretinoin therapy.



Facial paralysis, Isotretinoin, Drug withdrawal

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