DOI: http://dx.doi.org/10.18203/issn.2454-2156.IntJSciRep20200645

Effect of dietary chitosan on the feed efficiency and weight performance of high fat diet induced hyperlipidemia in male wistar rat

Kunle Ogungbemi, Regina N. Ugbaja, Funmilayo F. Ilesanmi, Abolanle O. Ilori, Toluwalope A. Odeniyi, Boluwaji M. Adeniyi, Daniel A. Balogun, Segun S. Ajisafe

Abstract


Background: This study was carried out to determine the growth performance of rats fed graded levels of chitosan supplemented High fat diet.  

Methods: Thirty male wistar rats weighing between 70 g and 90 g were purchased and randomly allotted into three (3) treatment groups with graded levels of chitosan in High fat diet (1%, 3% and 5%) and three (3) control groups namely: normal diet, High fat diet and normal diet +5% chitosan. The feed intakes as well as weight change of the experimental rats were monitored for six (6) weeks.

Results: The results obtained showed that the highest level of feed intake and feed efficiency were recorded for animals in group fed 5% level of chitosan supplementation when compared to other treatment groups. Similar result was observed for the weight change (as there was significant reduction in the weight gain with increase chitosan supplementation in HFD) which can be attributed to the efficient utilization of feed consumption.

Conclusions: It can be concluded that dietary chitosan prevents excess weight gain in hyperlipidemia and improves the overall nutritional attributes of the experimental diets by improving their feed efficiencies as compared to the control.


Keywords


Chitosan, Feed intake, Feed efficiency, Weight performance, Hyperlipidemia

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References


Yamada M, Honma I. Anhydrous proton conductive membrane consisting of chitosan. Electrochimica Acta. 2005 5;50(14):2837-41.

Dutta PK, Dutta J, Tripathi VS, Chitin and chitosan: Chemistry, properties and applications. J Sc Ind Res. 2004;63:20-31.

Maezaki Y, Tsuji K, Nakagawa Y, Kawai Y, Akimoto M, Tsugita T, Takekawa W, Terada A, Hara H, Mitsuoka T. Hypocholesterolemic effect of chitosan in adult males. Biosci Biotech Biochem. 1993;57(9):1439-44.

Ilium L. Chitosan and its use as a pharmaceutical excipient. Pharma Res. 1998;15(9):1326-31.

Jennings CD, Boleyn K, Bridges SR, Wood PJ, Anderson JW. A comparison of the lipid-lowering and intestinal morphological effects of cholestyramine, chitosan, and oat gum in rats. Proceedings Society Exp Biol Med. 1988;189(1):13-20.

LeHoux JG, Grondin FR. Some effects of chitosan on liver function in the rat. Endocrinology. 1993;132(3):1078-84.

Lim BO, Yamada K, Nonaka M, Kuramoto Y, Hung P, Sugano M. Dietary fibers modulate indices of intestinal immune function in rats. J Nutr. 1997;127(5):663-7.

Miura T, Usami M, Tsuura Y, Ishida H, Seino Y. Hypoglycemic and hypolipidemic effect of chitosan in normal and neonatal streptozotocin-induced diabetic mice. Biol Pharma Bull. 1995;18(11):1623-5.

Pittler MH, Abbot NC, Harkness EF, Ernst E. Randomized, double-blind trial of chitosan for body weight reduction. Euro J Clin Nutr. 1999;53(5):379.

Wuolioki E, Hirvela T, Ylitalo P. Decrease in serum LDL cholesterol with microcrystalline chitosan. Methods Find Exp Clin Pharmacol. 1999;21(5):357-62.

Ginghina C, Bejan I, Ceck CD. Modern risk stratification in coronary heart disease. J Med Life. 2011;4(4):377.

Jain KS, Kathiravan MK, Somani RS, Shishoo CJ. The biology and chemistry of hyperlipidemia. Bioorganic Med Chem. 2007;15(14):4674-99.

Burrows F, Louime C, Abazinge M, Onokpise O. Extraction and evaluation of chitosan from crab exoskeleton as a seed fungicide and plant growth enhancer. Am. Eurasian J Agric Environ Sci. 2007;2(2):103-11.

Washinton DC. AOAC Official methods of analysis. 15th Association of Official Analysis Chemist. 2005: 774-784.

Pearson D. The chemical analysis of foods. 7th edition. Longman Group Ltd. 1976.

Ogungbemi K, Atawodi SE, Ishola DT, Ishola OT, Ilesanmi FF, Arowora KA. Performance characteristics of male wistar rats fed graded levels of stored powdered Corchorus olitorius. Int J Sci Rep. 2017;3(2):28-32.

Khambualai O, Yamauchi KE, Tangtaweewipat S, Cheva-Isarakul B. Effects of dietary chitosan diets on growth performance in broiler chickens. J Poultry Sci. 2008;45(3):206-9.

Muzzarelli RAA, Muzzarelli C. Chitin and chitosan hydrogels. In Handbook of hydrocolloids. 2009: 849-888.

Zhang HL, Tao Y, Guo J, Hu YM, Su ZQ. Hypolipidemic effects of chitosan nanoparticles in hyperlipidemia rats induced by high fat diet. International Immunepharmacol. 2011;11(4):457-61.