Utility of serum gamma glutamyl transferase activity among hypertensive patients


  • Saroj Kunwar Department of Biochemistry, Modern Technical College, Sanepa, Lalitpur
  • Luniva Maharjan Department of Medical Laboratory Technology, Modern Technical College, Sanepa, Lalitpur
  • Bimal Chaulaigai Department of Medical Laboratory Technology, Modern Technical College, Sanepa, Lalitpur
  • Sanjay Kumar Sah Department of Biochemistry, National Medical College and Teaching Hospital, Birgunj




Hypertension, Gamma glutamyl transferase, Kidney disease


Background: Hypertension, a chronic medical condition of elevated blood pressure in the arteries. It is an emerging problem worldwide and one of the identifiable cause of kidney disease. Gamma glutamyl transferase (GGT) plays essential role in the metabolism of glutathione which is reported as major antioxidant. More recently increased GGT is associated with pathogenesis of hypertension. This study was aimed to determine activity of gamma glutamyl transferase in hypertensive patients.

Methods: All together 150 participants were recruited from Department of Medicine, Star Hospital for this hospital based cross-sectional study. Among which 50 were normotensive, 50 were pre-hypertensive and 50 were hypertensive. Blood sample were collected and analyzed in autoanalyser by enzymatic method.  

Results: Mean serum gamma glutamyl transferase activity is significantly different among normotensive, prehypertensive and hypertensive groups (i.e., 10.3 IU/l, 26.8IU/l and 37.2 IU/l respectively). Serum gamma glutamyl transferase activity is significantly higher in prehypertensive patients than normotensive group (p=0.001). Similarly GGT activity is significantly increased in hypertensive patients than prehypertensive patients (p=0.001).

Conclusions: Serum gamma glutamyl transferase activity is raised in prehypertensive and hypertensive participants as compared to normotensive. Thus Serum gamma glutamyl transferase level can have potential role on management of hypertension.


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Author Biography

Luniva Maharjan, Department of Medical Laboratory Technology, Modern Technical College, Sanepa, Lalitpur

Lecturer, Department of Biochemistry


Vaidya A, Pathak RP, Pandey MR. Prevalence of hypertension in Nepalese community triples in 25 years: a repeat cross-sectional study in rural Kathmandu. Indian Heart J. 2012;64(2):128-31.

Meister A, Anderson ME. Glutathione. Ann Rev Biochem. 1983;(52):711-60.

Whitfield JB. Gamma Glutamyl Transferase. Critical Rev Clin Laboratory Sci. 2001;38(4):263-355.

Lee DH, Jacobs DR. Is serum gamma-glutamyl transferase a marker of exposure to various environmental pollutants? Free Radical Res. 2009;43(6):533-7.

Lee DS, Evans JC, Robins SJ, Wilson PW, Albano I, Fox CS, et al. Gamma-glutamyltransferase and metabolic syndrome, cardiovascular disease, and mortality risk: The Framingham Heart Study. Arterioscler Thromb Vasc Biol. 2007;27:127-33.

Kamara K, Wilson OWA, Papalia Z, Bopp M, Bopp CM. Comparison of College Student Hypertension Prevalence between the JNC7 and ACC/AHA Diagnostic Criteria. Int J Exerc Sci. 2019;12(3):898-903.

Karakurt O, Çagirci G, Eryasar NE. Gamma-glutamyl transferase activity increases inprehypertensive patients. Turk J Med Sci. 2011;41(6):975-80.

Xuzen QIN, Guodong T, Ling Q, Xinq C, Shaomei H, Yajun L, et al. Association between γ-glutamyltransferase and prehypertension. Mol Med Report. 2012;5:1092-8.

Lee DH, Jacobs DR, Gross M, Kiefe CI, Roseman J, Lewis CE, et al. Gamma glutamyltransferase is a predictor of incident diabetes and hypertension: the Coronary Artery Risk Development in Young Adults (CARDIA) Study. Clin Chem. 2003;49:1358-66.

Lee DH, Silventoinen K, Hu G, Jacobs DR, Jousilahti P, Sundvall J, et al. Serum gamma-glutamyltransferase predicts non-fatal myocardial infarction and fatal coronary heart disease among 28,838 middle-aged men and women. Eur Heart J. 2006;27:2170-6.

Dan S, Banerjee I, Roy H, Roy S, Jana T, Dan S. Association Between Serum Gamma-glutamyl Transferase Level and Hypertension in Indian Adults: A Population Based Cross-Sectional Study. N Am J Med Sci. 2012;4(10):496-8.

Pizzorno J. Glutathione. Integr Med (Encinitas). 2014;13(1):8-12.

Tao L, Li X, Zhu H, Gao Y, Luo Y, Wang W, et al. Association between γ-glutamyl transferase and metabolic syndrome: a cross-sectional study of an adult population in Beijing. Int J Environ Res Public Health. 2013;10(11):5523-40.

Choi JW. Association between elevated serum hepatic enzyme activity and total body fat in obese humans. Ann Clin Lab Sci. 2003:33:257-64.

Elshorbagy AK, Refsum H, Smith AD, Graham IM. The association of plasma cysteine and gamma-glutamyltransferase with BMI and obesity. Obesity. 2009;17:1435-40.

Salvaggio A, Periti M, Miano L, Tavanelli M, Marzorati D. Body Mass Index and Liver Enzyme Activity in Serum. Clin Chem. 1991;37(5):720-3.

Park JM, Lee J, Lee DC, Lee YJ. Serum γ‐glutamyltransferase level and metabolic syndrome in children and adolescents: Korean National Health and Nutrition Examination Survey. J Diabetes Invest. 2017;9(3):522-8.






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