Hematological and biochemical studies on hemodylitic patients at the Government General Hospital, Wadi Al-Dawaser

Authors

  • Somia A. Nassar Department of Medical Laboratory Science, College of Applied Medical Science, Prince Sattam bin Abdul Aziz University, Wadi Addawasir, KSA
  • Zeinb A. Yehia Department of Biology, College of Art and Science, Prince Sattam bin Abdul Aziz University, Wadi Addawasir, KSA
  • Alaa A. Alnami Laboratory specialist
  • Alanood N. Aldosari Laboratory specialist
  • Sara M. Abdullah Laboratory specialist
  • Haya N. Aldosari Laboratory specialist

DOI:

https://doi.org/10.18203/issn.2454-2156.IntJSciRep20200047

Keywords:

Renal failure, Hemodialysis, Hemogram, Urea, Creatinine

Abstract

Background: Renal failure is a slowly progressive disease of kidney, characterized by low glomerular filtration. One of the most important replacement therapy of renal failure is hemodialysis which helping in the removal of toxic fluids and metabolic end products from the body.

Methods: This study was carried out on 43 patients with renal failure in the dialysis unit of Wadi Al-Dawaser General Hospital. Patients were 25 males and 18 females, randomly selected for the study between September and November 2018. Blood samples were obtained from all patients pre and post dialysis for serum biochemical analysis including kidney function test, liver function, lipid profile, glucose, electrolytes, while blood sample with anticoagulants collected pre dialysis for complete blood picture.  

Results: The hemogram parameters recorded significant decrease while leuckogram insignificantly increase specially eosinophils, in pre-dialysis patients. Serum biochemical parameters were significantly high pre-dialysis recorded 83.7%, 97.7%, 21% for urea, creatinine and uric acid respectively, while significantly decrease post dialysis. In contrast serum glucose and magnesium levels were significantly high pre and post dialysis. As result of decrease of the erythropoietin production in chronic renal failure patients lower hematological indices, increase the risk of anemia are main results.

Conclusions: Dialysis improve the biochemical parameters of serum especially creatinine and urea while glucose and magnesium not improved.

 

Metrics

Metrics Loading ...

Author Biography

Somia A. Nassar, Department of Medical Laboratory Science, College of Applied Medical Science, Prince Sattam bin Abdul Aziz University, Wadi Addawasir, KSA

College of Applied Medical Science - Department of Medical Laboratory Science

References

Suresh M, Mallikarjunareddy N, Sharan B, Bandi HK, Shravyakeerthi G, Chandrasekhar M. Hematological Changes in Chronic Renal Failure. Int J Sci Res Publications. 2012;2(9):1-4.

Alpers CE, Kumar V, Abbas AK, Fausto N, Robbins. Pathologic basis of kidney disease. Seventh edition, Elsevier Inc. 2004;20:960-5.

Poothullil J, Shimizu A, Day RP, Dolovich J. Anaphylaxis from the product (s) of ethylene oxide gas. Ann. Intern. Med. 1975;82(1):58-60.

Dodds A, Nicholls M. Haematological aspects of renal disease. Medline. 1983;11(4): 361-8.

Kovesdy CP, Kalantar-Zadeh K. Bone and mineral disorders in pre-dialysis CKD. Int Urol Nephrol. 2008;40(2):427-40.

National Kidney Foundation. K/DOQI Clinical Practice Guidelines for Anemia of Chronic Kidney Disease. Am J Kidney Dis. 2006;47(3):33-53.

Waknine Y. Kidney disease mortality rates continue to increase. Medscape Medical News, Morbidity and Mortality. 2007.

Faissal AM, Shaheen Abdullah A, AL-Khader. Preventive strategies of renal failure in the Arab world. Kidney International. 2005;68(98):37-40.

Raghunandan S, Deepak Kumar S, Ram Lakhan M. Effectiveness of Self Instructional Module (SIM) on knowledge regarding home care management among patients with chronic renal failure undergoing haemodialysis at selected hospital of Punjab. IOSR J Nurs Health Sci. 2016;5:20-31.

Kuddus M, Nawaf OM, Alhazmi Mohammed RM, Alshammari Rasheed HR, Alshortan Ahmad F, Alhaysuni Syed MA, et al. Correlation of minerals and glycated hemoglobin (HbA1c) in renal dialysis patients of Hail, Saudi Arabia. Int J Pharm Res Allied Sci. 2016;5(3):297-306.

Wendy E, Bloembergen DC, Friedrich K. Relationship of dose of hemodialysis and cause-specific mortality. Kidney Int. 1996;50:557-65.

Toma I, Marinho JS, Limeres JJ. Changes in salivary composition in patients with renal failure. Arch. Oral Biol. 2008;53:528-32.

Daugirdas JT, Ing TS, Roxe DM, Ivanovich PT, Krumlovsky F, Popli S, et al. Severe anaphylactoid reactions to cuprammonium cellulose hemodialyzers. Arch Internal Med. 1985;145(3):489-94.

Bijlani RL. Apllied renal physiology. In: Understanding medical physiology. Third edition. New Delhi : JP Brothers; 2004;8(4):522-23.

Al‐Nuaim AR. Prevalence of glucose intolerance in urban and rural communities in Saudi Arabia. Diabet Med. 1997;14:595-602

Jeng MR, Glader B, John P, Forester GJ, Lukens JN, Rodgers GM, et al. Acquired nonimmune hemolytic disorders. Eleventh edition, Wintrobe’s Clin Hematol; 2004;1:1239.

Robert T, Means Jr, John P, Forester GJ, John N, Lukens GM, et al. Anemias secondary to chronic disease and systemic disorders. Eleventh edition, Wintrobe’s Clin Hematol. 2004;47:1451-5.

Dessypris EN, Stephen Sawyer T. Erythropoiesis. Wintrobe’s clinical hematology. Eleventh edition. 2004;1:208-12.

Gouva CH, Papavasiliou E, Katopodis KP, Tambaki AP, Christidis D, Tselepis AD. Effect of Erythropoietin on Serum paf-acetylhydrolase in patients with Chronic Renal Failure. Nephrol Dialysis Transplant. 2006;21(5):1270-7.

Akinsola A, Durosinmi MO, Akinola NO. The haematological profile of Nigerians with chronic renal failure. Africa J Medic Med Sci. 2000;29(1):13-6.

Oluboyede OA, Williams AIO. Serum ferritin and other Iron Indices in Adult Nigerians with Chronic Renal Failure: Review of Management of Anaemia. Afr J Med Med Sci. 1995;24:231-7.

John P, Forester GJ, John N, Lukens GM, Paraskevas RF, Glader B. Eleventh edition. Wintrobe’s Clin Hematol; 2004;63:1784.

Ben H, Areyeh, Gutman D. Saliva in diagnosis of oral and systemic diseases. Israel J Dent Med. 1977;26:5-9.

Meenakshi GG. Effect of Dialysis on Certain Biochemical Parameters in Chronic Renal Failure Patients. Int J Contemp Med Res. 2016;3(10):2869-71.

Cheng P, Xia Y, Peng C, Zhou Z. Evaluation of dialysis in patients with end-stage renal disease by salivary urea, creatinine and uric acid. Zhong Nan Da XueXueBao Yi Xue Ban. 2013;38:1260-3.

Blaine J, Chonchol M, Levi M. Renal control of calcium, phosphate, and magnesium homeostasis, Clin. J Am Soc Nephrol. 2015;10:1257-72.

Peacock M. Calcium metabolism in health and disease. Clin J Am Soc Nephrol. 2010;5:S23-S30.

Navarro-Gonzalez JF. Magnesium in dialysis patients: serum levels and clinical implications. Clin Nephrol. 1998;49(6):373-8.

Downloads

Published

2020-01-24

Issue

Section

Original Research Articles