Acute hepatitis induced by a single dose of hydroxychloroquine
DOI:
https://doi.org/10.18203/issn.2454-2156.IntJSciRep20204033Keywords:
Hydroxychloroquine, COVID-19, Icterus, HypersensitivityAbstract
Hydroxychloroquine (HCQ) is considered the drug of choice for prophylaxis of COVID-19. It is supposed to be a safe drug. Herein we describe a case where a single dose of HCQ has led to acute toxic hepatitis. A junior of CIMS, Bilaspur while working at surgery department took a single dose of HCQ and suffered from jaundice. This suggests that we cannot label any drug to be safe and should take drug only after proper medical consultation and prescription without which even a single dose can cause hypersensitivity reaction.
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References
Cortegiani A, Ingoglia G, Ippolito M, Giarratano A, Einav S. A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19. J Crit Care. 2020;57:279-83.
Li-Sheng W,Yi-ru W, Da-wei Y, Qing-quan L. A review of the 2019 Novel Coronavirus (COVID-19) based on current evidence. Int J Antimicrobial Agents. 2020;55(6):105948.
Tett SE, Cutler DJ, Day RO, Brown KF. Bioavailability of hydroxychloroquine tablet in healthy volunteers. Br J Clin Pharmac. 1989;27:771-9.
Singh AK. Diabetes and Metabolic Syndrome. Clin Res Rev. 2020;14(3):241-6.
Naranjo CA, Busto U, Sellers EM, Sander P, Ruiz I, Roberts EA et al. A method for estimating the probability of adverse drug reaction. Clin Pharmacol Ther. 1981;30:239-45.
Roque RM. Chloroquine and Hydroxychloroquine toxicity. Medscape. Available at: https://emedicine. medscape.com/article/1229016-overview. Accessed on 2 May 2020.
Liver Tox: Clinical and Research information on drug induced Liver Injury. Bethesda. National Institute of Diabetes and Digestive and Kidney disease. Available at https://www.niddk. nih.gov/news/archive/2013/livertox-new-online-resource-information-drug-induced-liver-injury. Accessed on 2 May 2020.
Abdel GSM. Hydroxychloroquine induced toxic hepatitis in a patient with SLE: A case report. Lupus. 2015;24(6):638-40.
Galvañ VG, Oltra MR, Rueda D, Esteben MJ, Redon J. Severe acute hepatitis related to hydroxychloro-quine in a woman with mixed connective tissue disease. Clin Rheumatol. 2007;26:971-2.