Uterine non-Hodgkin lymphoma: a case report and review of literatures
Keywords:Non-Hodgkin lymphoma, Uterine, Abnormal vaginal bleeding, Extra-nodal lymphoma, Case report
Primary extra nodal non-Hodgkin lymphomas of the genital tract are uncommon, and involvement of the uterine corpus is not only extremely rare but lacks pathognomonic signs and symptoms, resulting in delayed diagnosis and treatment. This prompted this case report of a multiparous lady who presented with recurrent bleeding per vaginam and progressive abdominal swelling that was initially suspicious of being uterine sarcoma, but histological analysis of excised sample was diagnostic of non-Hodgkin lymphoma of the uterus. The report also highlights the challenges to diagnosis and management in a resource poor setting where advanced diagnostic aids are not readily accessible. The diagnosis of uterine non-Hodgkin lymphoma, though uncommon, should be considered in any patient with an abdominal/pelvic mass and/or abnormal bleeding per vaginam.
Chesson BD, Fisher RI, Barrington SF, Cavalli F, Schwartz LH, Zucca E, et al. Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification. J Clin Oncol. 2014;32(27): 3059-68.
Rosenberg SA. Validity of the Ann Arbor staging classification for the Non-Hodgkin's Lymphomas. Cancer Treat Rep. 1997;61:1023-7.
Vang R, Medeiros J, Ha Cs, Deaver M. Non-Hodgkin's lymphoma involving the uterus: A clinicopathologic analysis of 26 cases. Mod Pathol. 2000;13(1):19-28.
Krol AD, le Cessie S, Snijder S, Kluin-Nelemans JC, Kluin PM, Noordijk EM. Primary extra nodal non-Hodgkin's lymphoma (NHL): the impact of alternative definitions tested in the Comprehensive Cancer Centre West population based NHL registry. Ann Oncol. 2003;14(1):131-9.
Perry AM, Diebold J, Nathwani BN, MacLennan KA, Muller-Hermelink HK, Bast M, et al. Non-Hodgkin lymphoma in the developing world :review of 4539 cases from the International Non-Hodgkin lymphoma Classification Project. Haematological 2016;11(10):1244-50.
Akinbami A, Dada M, Dosunmu A, Balogun M. Adult Haemato-oncology Cases: A Six Year Review at Lagos State University Teaching Hospital Ikeja. The Internet J Dental Sci. 2008;7:2.
Oluboyede OA, Olaofe WA, Esan GJ. Non Hodgkin Lymphoma in Ibadan, Nigeia. J Natl Med Assoc. 1977;69(7):499-502.
Otter R, Gerrits WB, vd Sandt MM, Hermans J, Willemze R. Primary extra nodal and nodal non-Hodgkin's lymphoma. A survey of a population-based registry. Eur J Cancer Clin Oncol. 1989;25 (8):1203-10.
Johannesson L, Mason J, Miller J, Selva-Nayagam S, Oehler MK. Primary Non-Hodgkin’s lymphomas of the uterus and uterine cervix. Oncol Cancer Case Rep. 2017;3:127.
Glass AG, Karnell LH, Menck HR. The National cancer data base report on non-Hodgkin's lymphoma. Cancer. 1997;80(12):2311-20.
Ugboko V,I. Oginni F.O, Adelusola K.A, Durosinmi M.A. Orofacial non-Hodgkin’s lymphoma in Nigerians. J oral Maxillofac. Surg. 2004;62(11):1347-50.
Akinde OR, Anunobi CC, Osunkalu OV, Phillips AA, Afolayan OM. The challenges of lymphoma diagnosis in a Tertiary Hospital in Lagos, Nigeria. J Clin Sci. 2016;13:58-71
Gijsbers van Wijk CM, van Vliet KP, Kolk AM. Gender perspectives and quality of care: towards appropriate and adequate health care for women. Soc Sci Med. 1996;43(5):707-20.
Frey NV, Svoboda J, Andreadis C, Tsai DE, Schuster SJ, Elstrom R, et al. Primary lymphomas of the cervix and uterus: The University of Pennsylvania's experience and a review of the literature. Leuk Lymphoma. 2006;47(9):1894-901.
Anagnostopoulos A, Mouzakiti N, Ruthven S, Herod J, Kotsyfakis M. Primary cervical and uterine corpus lymphoma; a case report and literature review. Int J Clin Exp Med. 2013;6(4):298-306.
Harris NL, Suly RE. Malignant lymphoma and granulocytic sarcoma of the uterus and vagina. Cancer. 1984;53:2530-45.
Durotoye I. Pattern of haematological malignancies in Ilorin, Nigeria: a ten -year review. J Hematol. 2008;5:1-7.
Babatunde A, Amiwero C, Olatunji P, Durotoye I. Pattern of haematological malignancies in Ilorin, Nigeria: a ten -year review. J Hematol. 2008;5:1-7.