A case control study: to evaluate the lipid profile in ischemic and hemorrhagic stroke
Keywords:Stroke, Total cholesterol, High density lipoprotein-cholesterol, Low density lipoprotein-cholesterol, Triglycerides
Background: Stroke, be it ischemia or hemorrhage, is the most common clinical manifestation of cerebrovascular disease of which more than 99% are due to arterial involvement and less than 1% due to venous involvement. The aim of the present study was to assess the lipid profile of patients with ischemic and hemorrhagic stroke and to compare it with control group.
Methods: This study was conducted in the Department of Medicine in collaboration with Department of Biochemistry between February 2018 to August 2018 on 50 patients of infarct and 50 patients of hemorrhagic stroke admitted in GMC Jammu and 50 healthy controls. Serum was analyzed for estimation of serum lipid profile including total cholesterol, triglyceride, high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C), by using fully automatic analyzer.
Results: More than 54% of patients and controls belonged aged more than 60 years, with a total of 81 males and 69 females. Mean values of total cholesterol (233.53±27.09 mg) and LDL (165.89±30.54 mg) showed up higher in hemorrhagic stroke patients however higher mean values of triglycerides (177.80±40.44 mg) showed up in ischemic stroke patients. Serum cholesterol was abnormal among 50% ischemic and 54% hemorrhagic patients. A significant association is found between raised cholesterol, LDL, abnormal HDL and ischemic stroke.
Conclusions: A significant rise in total cholesterol level was found in case of both the groups, therefore high risk patients with stroke should be regularly screened for serum lipid profile.
Katan M, Luft A. Global burden of stroke. Semin Neurol. 2018;38:208-11.
Chugh C. Acute Ischemic Stroke: management approach. Ind J Crit Care Med. 2019;23:140-6.
Banerjee KT, Das KS. Fifty years of stroke researchers in India. Ann Indian Acad Neurol. 2016,19:1-8.
Bohme KA, Esenwa C, Eskin Dm. Stroke risk factors, genetics and prevention. Circ Res. 2017;120:472-95.
Park HJ, Rozuk A, Sand FP, Karaknaina K, Rodriguez CA, Campas CA, et al. Carotid stenosis: what is the high risk population. Clinic. 2012,67:865-70
Musunuru K. Atherogenic Dyslipidemia: Cardiovascular risk and dietary intervention. Lipids. 2010;45:907-14.
World Health Organization. The world health report:shaping the future.Geneva:WHO;2003. Last Assessed on 12 January 2019.
Austin MA, King MC, Vranizan KM, Krauss RM. Atherogenic lipoprotein phenotype. A proposed genetic marker for coronary heart disease risk. Circulation. 1990;82:495-506.
Davenport R, Dennis M. J Neurol Neurosurg Psychiatry. 2000;68:277-88.
Qizilbash N, Duffy SW, Warlow C, Mann J. Cerebrovascular Diseases. Karger. 1992;2:127-36.
Bharosay A, Bharosay VV, Bandyopadhyay D, Sodani A, Varma M, Baruah H. Effect of lipid profile upon prognosis in ischemic and haemorrhagic cerebrovascular stroke. Ind J Clinic Biochem. 2014;29(3):372-6.
Gu X, Li Y, Chen S, Yang X, Liu F, Li Y, et al. Association of lipids with ischemic and hemorrhagic stroke: a prospective cohort study among 267 500 Chinese. Stroke. 2019;50(12):3376-84.
Nagasawa SY, Okamura T, Iso H, Tamakoshi A. Evidence for cardiovascular prevention from observational cohorts in japan research group. Relationship between serum cholesterol level and cardiovascular disease stratified by sex and age group: a pooled analysis of 65594 individuals from 10 cohort studies in Japan. J Am Heart Assoc. 2012:12:243-56.
Khan J, Shah AA, Jielani A. Frequency of hypertension in stroke patients presenting at Ayub Teaching Hospital. J Ayub Med Col Abbottabad. 2006;18(1).
Chaudhury SR, Ghosh S, Kar D. Comparative lipid profile study between ischemic and hemorrhagic stroke. J Chem Pharm Res. 2014;6(11):20-7.