DOI: http://dx.doi.org/10.18203/issn.2454-2156.IntJSciRep20212833

Assessment of knowledge, attitude and practice of pharmacovigilance and adverse drug reactions reporting among the community pharmacies in Dharan

Kadir Alam, Badri Karki, Amit Kumar Gupta, Deependra Prasad Sarraf, Subash Wagle

Abstract


Background: Community pharmacist’s (CPs) knowledge, attitude and practice (KAP) of pharmacovigilance and adverse drug reactions (ADR) play a vital role in preventing harmful effects of medicine. The objective was to assess the KAP of pharmacovigilance and ADR reporting among CP.

Methods: A cross-sectional study was carried out among 132 CP in Dharan between February-March 2019 by using a self-administered 25-item semi-structured questionnaire. The KAP score was categorized as good (score 13-25) and poor (score 0-12). The descriptive statistics were calculated using Microsoft excel 2010.

Results: Out of 132 pharmacies, only 77 responded giving a response rate of 58.3%. There were 45 (58.4%) male. Majority of the participants (45, 58.4%) had completed diploma in pharmacy course. Only 23 (29.9%) respondents gave the correct responses regarding the definition of pharmacovigilance and 23.4% were aware of the national pharmacovigilance centre. 50.9% agreed that reporting of ADRs is a part of pharmacist duty and it was important to report ADRs and was leading cause of hospitalization. Sixty three (81.8%) participants had never ever been trained on how to report ADR. Seventy (90.9%) participants were willing to report ADR, however, 51 (66.2%) had never seen the ADR reporting form. Only 3 (3.9%) participants had good KAP score (23.33±1.54).

Conclusions: Despite of relatively better attitude towards pharmacovigilance and ADR reporting, they had a limited knowledge and practice with regard to ADR reporting and pharmacovigilance. The study findings highlights the need to strengthen the community pharmacovigilance program for safer medication use at the community level.


Keywords


Adverse drug reaction, Attitude, Knowledge, Practice, Pharmacovigilance

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References


Coleman JJ, Pontefract SK. Adverse drug reactions. Clin Med (Lond). 2016;16(5):481-5.

Amin MN, Khan TM, Dewan SM, Islam MS, Moghal MR, Ming LC. Cross-sectional study exploring barriers to adverse drug reactions reporting in community pharmacy settings in Dhaka, Bangladesh. BMJ Open. 2016;6(8):010912.

Pirmohamed M, James S, Meakin S, Green C, Scott AK, Walley TJ, et al. Adverse drug reactions as cause of admission to hospital: prospective analysis of 18,820 patients. BMJ. 2004;329(7456):15-9.

Lazarou J, Pomeranz BH, Corey PN. Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies. JAMA. 1998;279(15):1200-5.

Ramesh M, Pandit J, Parthasarathi G. Adverse drug reactions in a south Indian hospital--their severity and cost involved. Pharmacoepidemiol Drug Saf. 2003;12(8):687-92.

WHO. Fact sheet: Pharmacovigilance: ensuring the safe use of medicines,Geneva, 2004. Available at: https://apps.who.int/iris/handle/10665/68782. Accessed on 9 January 2019.

AbdulRazzaq HA, Aziz NA, Sulaiman SAS, Hassan Y, Kassab YW, Ismail O. Adverse drug reactions of statin based on patients’ self-reports. J Pharm Res. 2012;5(2):864-8.

Santosh KC, Tragulpiankit P, Gorsanan S, Edwards IR. Attitudes among healthcare professionals to the reporting of adverse drug reactions in Nepal. BMC Pharmacol Toxicol. 2013;14:16.

Jha N, Shankar PR, Bajracharya O, Gurung SB, Singh KK. Adverse drug reaction reporting in a pharmacovigilance centre of Nepal. Australas Med J. 2012;5(5):268-71.

Department of Drug Administration. Fact sheet: Pharmacovigilance, 2017. Available at: https://www.dda.gov.np/content/pharmacovigilance. Accessed on 9 January 2019.

Bhuwan KC, Alrasheedy AA, Mohamed MI. Do community pharmacists in Nepal have a role in adverse drug reaction reporting systems? Australas Med J. 2013;6(2):100-3.

Dalton K, Byrne S. Role of the pharmacist in reducing healthcare costs: current insights. Integr Pharm Res Pract. 2017;6:37-46.

Ibrahim MIM. Assessment of medication dispensing and extended community pharmacy services. Social Administrative Aspects Pharmacy Low Middle Income Countries. 2018:295-309.

Raosoft. Fact sheet: Sample calculator. Available at: http://www.raosoft.com/samplesize.html. Accessed on 9 January 2019.

Sah RK, Chandane RD, Manocha S, Kapur A. Knowledge, attitude and practice of pharmacovigilance among community pharmacists in Delhi, India. Int J Basic Clinic Pharmacol. 2017;6(3):618-23.

Srinivasan V, Sheela D, Mridula D. Knowledge, attitude, and practice of pharmacovigilance among the healthcare professionals in a tertiary care hospital-a questionnaire study. Biomed Pharmacol J. 2017;10(3):1441-7.

Palaian S, Ibrahim MI, Mishra P. Health professionals' knowledge, attitude and practices towards pharmacovigilance in Nepal. Pharm Pract (Granada). 2011;9(4):228-35.

Piparva KG, Singh AP. A cross sectional pilot study of knowledge, attitude and practice of pharmacovigilance among pharmacists at Rajkot district. J Basic Clin Pharma. 2017;8:20-3.

Srikanth MS, Adepu R, Patel H, Parthasarathi G. A study of knowledge, attitude and practice of community pharmacists towards adverse drug reaction reporting and monitoring. Value Health. 2015;18:335-766.

Madu EP, Eneta BEL. A study on the knowledge and barriers towards ADRs reporting among community pharmacists in Enugu and Nsukka areas, South-Eastern Nigeria. PTB Reps. 2017;3(1):1-6.

Prakasam A, Nidamanuri A, Kumar S. Knowledge, perception and practice of pharmacovigilance among community pharmacists in South India. Pharmacy Practice (Internet). 2012;10(4):222-6.

Suyagh M, Farah D, Farha RA. Pharmacist’s knowledge, practice and attitudes toward pharmacovigilance and adverse drug reactions reporting process. Saudi Pharm J .2015:23;147-53.

Envans SM, Berry JG, Smith BJ, Esterman A, Selim P, Oshanghnessy J, et al. Attitudes and barriers to incident reporting: a collaborative hospital study. Qual Saf Health Care. 2006;15:39-43.

Li R, Curtain C, Bereznicki L, Zaidi STR. Community pharmacists' knowledge and perspectives of reporting adverse drug reactions in Australia: a cross-sectional survey. Int J Clin Pharm. 2018;40(4):878-89.

Desai CK, Iyer G, Panchal J, Shah S, Dikshit RK. An evaluation of knowledge, attitude, and practice of adverse drug reaction reporting among prescribers at a tertiary care hospital. Perspect Clin Res. 2011;2:129-36.

Sivadasan S, Yuong NY, Chyi NW, SiewChing AL, Ali AN, Veerasamy R, et al. Knowledge and perception towards pharmacovigilance and adverse drug reaction reporting among medicine and pharmacy students. WJPPS. 2014;3:1652-76.