DOI: http://dx.doi.org/10.18203/issn.2454-2156.IntJSciRep20212395

Hepatocellular carcinoma with extrahepatic adrenal metastasis: an atypical case report

Diptajit Paul, Baljit Singh, Rakesh Dhankhar, Vivek Kaushal

Abstract


Hepatocellular carcinoma with extrahepatic metastasis are a threat to public health worldwide. Lung, bones and abdominal lymph nodes are the major sites of metastasis from liver primary, adrenal metastasis being a less common site. Here we present an old male presented with upper abdominal pain diagnosed as advanced, unresectable hepatocellular carcinoma with right adrenal metastasis. Patient was treated with multi-kinase inhibitor sorafenib and outcome was acceptable with good patient compliance.


Keywords


Hepatocellular carcinoma, Right adrenal metastasis, Upper abdominal pain, Sorafenib

Full Text:

PDF

References


World Health Organization International Agency for Research on Cancer (IARC). GLOBOCAN 2020: Population Fact Sheets: World. 2020. Available at: https://gco.iarc.fr/today/fact-sheets-populations. Accessed on 04 May 2020.

Marino D, Zichi C, Audisio M, Sperti E, Di Maio M. Second-line treatment options in hepatocellular carcinoma. Drugs Context. 2019;8:212577.

Rimassa L, Santoro A. Sorafenib therapy in advanced hepatocellular carcinoma: the SHARP trial. Expert Rev Anticancer Ther. 2009;9(6):739-45.

Cheng AL, Kang YK, Chen Z, Tsao CJ, Qin S, Kim JS, et al. Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial. Lancet Oncol. 2009;10(1):25-34.

Yamashita T, Kudo M, Ikeda K, Izumi N, Tateishi R, Ikeda M, et al. REFLECT-a phase 3 trial comparing efficacy and safety of lenvatinib to sorafenib for the treatment of unresectable hepatocellular carcinoma: an analysis of Japanese subset. J Gastroenterol. 2020;55(1):113-22.

Uchino K, Tateishi R, Shiina S, Kanda, M, Masuzaki R., Kondo Y et al Hepatocellular carcinoma with extrahepatic metastasis. Cancer. 2011;117:4475-83.

Nugroho A, Lee KW, Lee KB, Kim HS, Kim H, Yi NJ, Suh KS. Adrenal metastasis in sequentially developed combined hepatocellular carcinoma-cholangiocarcinoma: A case report. Ann Hepatobiliary Pancreat Surg. 2018;22(3):287-91.

Mao K, Wang J. Present treatment situation of hepatocellular carcinoma with extrahepatic metastasis. Zhonghua Wai Ke Za Zhi. 2019;57(6):466-70.