IL1B rs1143634 (+3953) variant associated with severe dengue in Brazilian children

Authors

  • Yerly M. Useche Research Group on Molecular Genetics (GENMOL), Biology Institute, University of Antioquia, Medellín, Colombia http://orcid.org/0000-0003-3912-0707
  • Marcelo Ribeiro-Alves National Institute of Infectology Evandro Chagas, Oswaldo Cruz Foundation, Laboratory of Clinical Research in STD/AIDS, Rio de Janeiro, Brazil
  • Caroline Xavier-Carvalho Leprosy Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil
  • Cynthia C. Cardoso Molecular Virology Laboratory, Department of Genetics, Institute of Biology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
  • Claire F. Kubelka Viral Immunology Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil
  • Milton O. Moraes Leprosy Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil
  • Gabriel Bedoya-Berrio Research Group on Molecular Genetics (GENMOL), Biology Institute, University of Antioquia, Medellín, Colombia

DOI:

https://doi.org/10.18203/issn.2454-2156.IntJSciRep20214103

Keywords:

SNPs, Severe dengue, IL1B, Association

Abstract

Several variants involved in the expression of proteins related to immunopathological mechanisms have been associated with dengue, but few specifically related to severe dengue. In addition, children are a group with a high incidence and mortality rate due to dengue. Several immunopathological processes developed specifically in children affected with severe dengue partially explain this risk condition. This case-control retrospective study aimed to examine the association of variants in CD209, NFKBIA, IL12B, and IL1B genes with severe dengue. These genes encode proteins involved in one of the main pathways of the immune response against dengue virus infection. The study population included affected children and householding controls from Brazil. Genotyping was performed with Real-Time TaqMan assays, and the association analysis was performed with conditional logistic regressions. We found the IL1B rs1143634 genotypes carrying the T allele to be associated with susceptibility to severe dengue in children. The lower circulating levels of IL-1β associated with carrying the T allele of the IL1B rs1143634 suggest a role of this cytokine in the impairment of the immune response and plasma leakage, and, consequently, in the development of severe dengue.

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Author Biography

Yerly M. Useche, Research Group on Molecular Genetics (GENMOL), Biology Institute, University of Antioquia, Medellín, Colombia

Laboratory on Thymus Research, Oswaldo Cruz Institute,

Oswaldo Cruz Foundation.


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Published

2021-10-22

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Short Communication