DOI: http://dx.doi.org/10.18203/issn.2454-2156.IntJSciRep20150355

Primary thyroid lymphoma: a comprehensive summary of two cases

Sonam Sharma, Devashis Mandal, Amit K. Yadav, Ashish K. Mandal

Abstract


Thyroid lymphoma occurs rarely; constituting approximately 1-5% of all thyroid malignancies. Two cases of thyroid lymphoma are presented herewith. Both the patients were elderly females who presented with a rapidly enlarging anterior neck mass without cervical lymphadenopathy, leading to compressive symptoms like dysphagia, stridor and dyspnoea. Thyroid lymphoma is a great diagnostic and therapeutic challenge which requires high clinical suspicion with rapid and accurate diagnostic modalities to detect it as early recognition of this rare malignancy can lead to timely intervention and avoid morbidity associated with extensive surgery as chemotherapy and radiation are the mainstays of its treatment.


Keywords


Thyroid, Lymphoma, FNAC, Immunocytochemistry, Therapy

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References


Kumar R, Khosla D, Kumar N, Ghoshal S, Bera A, Das A, et al. Survival and failure outcomes in primary thyroid lymphomas: a single centre experience of combined modality approach. J Thyroid Res. 2013;2013:269034.

Ha CS, Shadle KM, Medeiros LJ, Wilder RB, Hess MA, Cabanillas F, et al. Localized non-Hodgkin lymphoma involving the thyroid gland. Cancer. 2001;91(4):629-35.

Gupta N, Nijhawan R, Srinivasan R, Rajwanshi A, Dutta P, Bhansaliy A, et al. Fine needle aspiration cytology of primary thyroid lymphoma: a report of ten cases. Cytojournal. 2005;2:21.

Austin JR, el‑Naggar AK, Goepfert H. Thyroid cancers. II. Medullary, anaplastic, lymphoma, sarcoma, squamous cell. Otolaryngol Clin North Am. 1996;29:611-27.

Ansell SM, Grant CS, Habermann TM. Primary thyroid lymphoma. Semin Oncol. 1999;26(3):316-23.

Verma D, Puri V, Agarwal S, Bhaskar A. Primary thyroid lymphoma: a rare disease. J Cytol. 2014;31:218-20.

Hyjek E, Isaacson PG. Primary B-cell lymphoma of the thyroid and its relationship to Hashimoto’s thyroiditis. Hum Pathol. 1988;19:1315.

Thieblemont C, Mayer A, Dumontet C, Barbier Y, Callet-Bauchu E, Felman P, et al. Primary thyroid lymphoma is a heterogeneous disease. J Clin Endocrinol Metab. 2000;87:105-11.

Sangalli G, Serio G, Zampatti C, Lomuscio G, Colombo L. Fine needle aspiration cytology of primary lymphoma of the thyroid: a report of 17 cases. Cytopathology. 2001;12:257-63.

Daneshbod Y, Omidvari S, Daneshbod K, Negahban S, Dehghani M. Diffuse large B-cell lymphoma of thyroid as a masquerader of anaplastic carcinoma of thyroid, diagnosed by FNA: a case report. Cytojournal. 2006;3:23.